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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Struktur
745055-86-1
CAS-Nr.
745055-86-1
Englisch Name:
(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
Synonyma:
UBP 296;(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
CBNumber:
CB7460159
Summenformel:
C15H15N3O6
Molgewicht:
333.3
MOL-Datei:
Mol file

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Eigenschaften

Schmelzpunkt:
190.8-191.2 °C (decomp)(Solv: water (7732-18-5))
Siedepunkt:
603.0±65.0 °C(Predicted)
Dichte
1.525±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
<3.33mg/ml in 1eq. NaOH; <3.33mg/ml in DMSO
pka
2.12±0.10(Predicted)

Sicherheit

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

UBP 296 is a novel, potent and selective kainate receptor antagonist.

Biologische Aktivit?t

Selective and potent GluR5-subunit containing kainate receptor antagonist (apparent K D = 1.09 mM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
  • UBP 296
  • 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
  • 745055-86-1
  • Glutamate receptor
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