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XAP044

XAP044 Struktur
196928-50-4
CAS-Nr.
196928-50-4
Englisch Name:
XAP044
Synonyma:
XAP044;XAP044, 10 mM in DMSO;mGlu7 Antagonist, XAP044;7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-;XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
CBNumber:
CB73152769
Summenformel:
C15H9IO4
Molgewicht:
380.13
MOL-Datei:
196928-50-4.mol

XAP044 Eigenschaften

Siedepunkt:
485.7±45.0 °C(Predicted)
Dichte
1.853±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
≤10mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
Aggregatzustand
crystalline solid
pka
6.70±0.20(Predicted)
Farbe
white to beige

Sicherheit

XAP044 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.

Verwenden

XAP 044 is a potent mGlu7 antagonist used in the treatment of anxiety and depression in mice (1,2). Applications towards stress, autism and drug abuse are also potential uses.

XAP044 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

XAP044 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 48)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 32298 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9803 58
Block Chemical Technology (Shanghai) Co., LTD 021-20432219 13918097649
 li_jinfei@acblock-lab.com China 9451 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551
 15151849396@163.com China 997 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44813 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24958 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 5619 58
RD International Technology Co., Limited 18024082417
 market@ubiochem.com China 9835 58
  • XAP044
  • 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
  • 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-
  • 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
  • XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
  • XAP044, 10 mM in DMSO
  • mGlu7 Antagonist, XAP044
  • 196928-50-4
  • C15H9IO4
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