Anti-Q10 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-AGO2 antibody produced in rat has been used in:
- immunofluorescent localization
- western blot analysis
- immunoprecipitation.
Allgemeine Beschreibung
Monoclonal Anti-AGO2 (rat IgG2a isotype) is derived from the hybridoma 11A9 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from rat immunized with a peptide corresponding to amino acids 1-15 of human AGO2. Monoclonal Anti-AGO2 recognizes human, monkey, bovine, rat and mouse AGO2. Argonaute 2 (Ago2) is encoded by the gene mapped to human chromosome 8q24.3. The encoded protein belongs to the Ago protein family. AGO2 is mainly localized on the diffuse cytoplasm and stress granules.
Biochem/physiol Actions
Argonaute 2 (Ago2) plays a vital role in short interfering RNA-mediated gene silencing. The encoded protein is regulated at both the transcriptional and posttranslational level in human breast cancer cell lines. Ago2 and enhanced micro-RNA activity is involved in the tumorigenic progression of breast cancer cell lines. Overexpression of the gene has been observed in hepatocellular carcinoma (HCC), head and neck squamous cell carcinoma patients.
Anti-Q10 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
