Indacaterol Maleate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
Verwenden
A long-acting β2 adrenoreceptor agonist and bronchodilator, for the treatment of asthma and chronic obstructive pulmonary disease.
Definition
ChEBI: A maleate salt obtained by reaction of indacaterol with one equivalent of maleic acid. Used for treatment of chronic obstructive pulmonary disease.
Trademarks
Indacaterol is provided as its maleate salt form. It is marketed in Europe as Onbrez and in America as Arcapta Neohaler.
Clinical Use
Indacaterol is a b-adrenoceptor agonist currently approved in
Europe as Onbrez, and is marketed by Novartis. It needs to be
taken only once a day, unlike competitors formoterol and salmeterol.
These drugs are used in the treatment of chronic obstructive
pulmonary disease (COPD) and asthma. Onbrez is administered via
an aerosol formulation through a dry powder inhaler. A Phase III
trial published in July 2010 suggested that indacaterol is significantly
more effective than twice-daily formoterol in improving
FEV1 and reduces the need for rescue medication.
Nebenwirkungen
combination of sore throat, runny nose, blocked nose, sneezing; coughing; headache with or without fever; sneezing; muscle pain; muscle spasm; swollen hands, ankles and feet; crushing chest pain (heart problems); neck pain; palpitations (feeling that your heartbeat is unusually fast or irregular); headache; sore throat; cough; runny nose; blocked nose; dry mouth; feeling pressure or pain in the cheeks and forehead (inflammation of the sinuses); chest pain; chest discomfort; pain in muscles, bones or joints; excessive thirst, high urine output, increase appetite with weight loss and tiredness, high level of sugar in the blood (that are signs of a disease called diabetes); tingling and numbness; dizziness vertigo
Indacaterol Maleate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
