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SMER 3

SMER 3 Struktur
67200-34-4
CAS-Nr.
67200-34-4
Englisch Name:
SMER 3
Synonyma:
SMER 3;SMER3(SMER 3);5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;SMER3, SCFMet30 ubiquitin E3 ligase inhibitor;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
CBNumber:
CB72565931
Summenformel:
C11H4N4O2
Molgewicht:
224.18
MOL-Datei:
67200-34-4.mol

SMER 3 Eigenschaften

Schmelzpunkt:
283-284 °C(Solv: ethanol (64-17-5))
Siedepunkt:
437.2±55.0 °C(Predicted)
Dichte
1.665±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥30mg/mL
pka
-8.15±0.20(Predicted)
Aggregatzustand
powder
Farbe
yellow
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  1
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

SMER 3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.

Verwenden

SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.

SMER 3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SMER 3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 74)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10311 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070
info@chemlin.com.cn China 19182 64
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811783
sales@trio-pharmatech.com (International market) China 1856 62
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 14055 65
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489
Sales-JP@TCIchemicals.com Japan 28387 80

67200-34-4()Verwandte Suche:


  • SMER 3
  • 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
  • 9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
  • OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
  • SMER3(SMER 3)
  • 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N
  • 5-oxoinden[1,2-e]furazano[3,4-b]pyrazine
  • Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
  • SMER3, SCFMet30 ubiquitin E3 ligase inhibitor
  • 67200-34-4
  • C11H4N4O2
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