COMU
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- CAS-Nr.
- 1075198-30-9
- Englisch Name:
- COMU
- Synonyma:
- {{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium;COMU(R) 97%;COMU ISO 9001：2015 REACH;elagolix intermediate 13;COMU NOVABIOCHEM(R) 25 G;(2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate;[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium;(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate;4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate;1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate
- CBNumber:
- CB72505584
- Summenformel:
- C12H19F6N4O4P
- Molgewicht:
- 428.2678402
- MOL-Datei:
- 1075198-30-9.mol
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COMU Eigenschaften
- Schmelzpunkt:
- ca 160℃
- storage temp.
- Store at -15°C to -25°C.
- L?slichkeit
- Soluble in DMF 1mmol in 2mL.
- Aggregatzustand
- Powder or Solid
- Farbe
- White to pale yellow
- Sensitive
- Air & Moisture Sensitive
- InChI
- InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
- InChIKey
- GPDHNZNLPKYHCN-DZOOLQPHSA-N
- SMILES
- C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F
COMU Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1].
Verwenden
COMU – Safer and More Efficient Peptide Coupling ReagentAdvantages
- Equal or even superior performance to HATU
- Non-explosive (does not contain benzotriazole moiety)
- Suitable for solution phase & solid phase peptide synthesis
- Utmost retention of configuration – low to non-existent racemization
- High solubility and stability in typical solvents
- Visual or colorimetric reaction monitoring possible
- Easy removal of water-soluble by-products
Allgemeine Beschreibung
This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention".
COMU Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
COMU Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 152)Lieferanten
- (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
- 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate
- 1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate
- (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate (This product is only available in Japan.)
- COMU(R) 97%
- elagolix intermediate 13
- COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
- [[(Z)-(1-Cyano-2-ethoxy-2-oxo-ethylidene)amino]oxy-morpholino-methylene]-dimethyl-ammonium hexafluorophosphate
- [[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium
- 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
- COMU ISO 9001：2015 REACH
- COMU NOVABIOCHEM(R) 25 G
- COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium,98%
- 4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate
- {[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosp
- 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium(COMU?)
- {{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium
- [[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium,hexafluorophosphate
- 4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate(V)
- N-1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholin-4-yl)uronium hexafluorophosphate
- (2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate
- 1075198-30-9
- C12H19N4O4PF6
- C12H19F6N4O4P
- C12H19N4O4F6P
