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4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Struktur
58131-57-0
CAS-Nr.
58131-57-0
Englisch Name:
4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
Synonyma:
XI-006;CS-230;NSC-207895;NSC 179940;XI-006，NSC-207895;NSC-207895 (XI-006);NSC-207895 NSC207895;XI-006 (NSC207895)=1119;4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide;7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide
CBNumber:
CB72382615
Summenformel:
C11H13N5O4
Molgewicht:
279.25
MOL-Datei:
58131-57-0.mol

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Eigenschaften

Siedepunkt:
487.6±55.0 °C(Predicted)
Dichte
1.64
storage temp. 
Store at -20°C
L?slichkeit
Limited solubility
Aggregatzustand
Powder
pka
6.23±0.42(Predicted)
Farbe
Brown to reddish brown
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P271, P304+P340, P312
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).

Verwenden

NSC-207895 is an anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2. It can also be used in pharmacological activity and therapeutic use of reviving antibiotics in relation to prepared efflux pump inhibitors that interact with AcrA, membrane fusion protein of AcrAB-TolC multidrug efflux pump.

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 89)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58

58131-57-0()Verwandte Suche:

  • 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide
  • 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
  • 7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide
  • XI-006 (NSC207895)=1119
  • NSC-207895
  • NSC-207895 (XI-006)
  • NSC 179940
  • 4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide
  • 2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide
  • XI-006
  • XI-006，NSC-207895
  • 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide USP/EP/BP
  • 7-(4-methylpiperazin-1-yl)-4-nitrobenzo[c][1,2,5]oxadiazole 1-oxide
  • CS-230
  • NSC-207895 NSC207895
  • 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium
  • 7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide
  • 58131-57-0
  • Inhibitors
  • Inhibitor
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