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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Struktur
648450-29-7
CAS-Nr.
648450-29-7
Englisch Name:
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
Synonyma:
AS605240;AS-605240, >=98%;AS-605240(AS 605240);PI 3-Kinase Inhibitor (AS605240);PI 3-Kγ Inhibitor AS-605240 AS605240;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, 98%, a specific inhibitor of PI3Kγ;PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem;5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
CBNumber:
CB72100624
Summenformel:
C12H7N3O2S
Molgewicht:
257.27
MOL-Datei:
648450-29-7.mol

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Eigenschaften

Dichte
1.553±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble1mg/mL, clear (warmed)
pka
6.02±0.20(Predicted)
Aggregatzustand
powder
Farbe
, faint red to orange to dark brown
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26
WGK Germany  3
HS Code  2934100090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Verwenden

AS605240 has been used:
  • as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
  • as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
  • as a class 1A PI3K inhibitor?to treat CD4+?T cells.

Biologische Aktivit?t

Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Biochem/physiol Actions

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 143)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 965 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
+86-86-22-87899925 +86-8618522618860
18522618860@163.com China 694 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
+86-519-85525359 +86-15995072465
sales@xuanmingchem.com China 914 58

648450-29-7()Verwandte Suche:


  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • AS605240
  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
  • PI 3-Kinase Inhibitor (AS605240) B-0301
  • AS-605240, >=98%
  • (E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione
  • 2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-
  • AS-605240(AS 605240)
  • (Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione AS-605240
  • AS-605240 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • AS-605240, 98%, a specific inhibitor of PI3Kγ
  • PI 3-Kinase Inhibitor (AS605240)
  • AS 605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
  • PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
  • 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione USP/EP/BP
  • 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
  • PI 3-Kγ Inhibitor AS-605240 AS605240
  • 648450-29-7
  • 348450-29-7
  • Inhibitors
  • API
  • Akt
  • mTOR
  • PI3K
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