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2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Struktur
72836-33-0
CAS-Nr.
72836-33-0
Englisch Name:
2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
Synonyma:
TIMTEC-BB SBB005594;2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE;5-((4-CHLOROBENZYL)THIO)-1,3,4-THIADIAZOL-2-AMINE;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-AMINE;[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]amine;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-YLAMINE;5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine;1,3,4-Thiadiazol-2-amine, 5-[[(4-chlorophenyl)methyl]thio]-;5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
CBNumber:
CB7208144
Summenformel:
C9H8ClN3S2
Molgewicht:
257.76
MOL-Datei:
Mol file

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Eigenschaften

Schmelzpunkt:
168-169 °C(Solv: ethyl acetate (141-78-6))
Siedepunkt:
443.8±47.0 °C(Predicted)
Dichte
1.50±0.1 g/cm3(Predicted)
pka
2.41±0.10(Predicted)

Sicherheit

Kennzeichnung gef?hrlicher Xi
Hazard Note  Irritant
HS Code  2934999090

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

An orally bioavailable, non-toxic, thio-thiadiazolamine compound that specifically inhibits the DNA-binding capacity of virulence regulator, RegA (IC50 = 1.7 μM in E. coli strain MC4100 (kfc-lacZ, pACYC184-regA), by interacting with amino acid residues within a conserved region of the DNA-binding domain, but without affecting RegA dimerization. Interacts with the double helix-turn-helix (HTH) domain that results in a loss of binding affinity of RegA for its DNA targets. This interaction appears to involve W188 and R223 residues that are conserved in several RegA homologs including ToxT, AggR, RegR, and Rns. Shown to be highly effective in reducing Citrobacter rodentium colonization when administered perorally to mice (~50 mg/kg) either 15 minutes before or 12 hours after bacterial inoculation. Reduces the ability of Rns and RegR to activate the transcription of their target promoters, but does not affect the activity of AggR and ToxT.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 12)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
 sales@hopschem.com China 31553 55
Nanjing Shizhou Biology Technology Co.,Ltd --
 purchase@synzest.com China 6857 58
  • TIMTEC-BB SBB005594
  • 5-((4-CHLOROBENZYL)THIO)-1,3,4-THIADIAZOL-2-AMINE
  • 5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-AMINE
  • 5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-YLAMINE
  • 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
  • 5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
  • 5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine
  • [5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]amine
  • 1,3,4-Thiadiazol-2-amine, 5-[[(4-chlorophenyl)methyl]thio]-
  • 72836-33-0
  • C9H8ClN3S2
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