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ANTI-INCENP

ANTI-INCENP Struktur
CAS-Nr.
Englisch Name:
ANTI-INCENP
Synonyma:
ANTI-INCENP;ANTI-INNER CENTROMERE PROTEIN;Anti-INCENP antibody produced in rabbit
CBNumber:
CB7159703
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-INCENP Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

WGK Germany  -

ANTI-INCENP Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-INCENP antibody produced in rabbit has been used in western blotting and immunofluorescence.

Allgemeine Beschreibung

The gene INCENP (inner centromere protein) encodes an inner centromere protein that forms a component of the chromosomal passenger complex (CPC). It is found to be localized to inner centromeres during mitosis. The CPC also contains Aurora B, survivin, and Borealin.

Biochem/physiol Actions

The inner centromere protein encoded by the INCENP gene is phosphorylated by Cdk1 (cyclin dependent kinase 1) in mitosis. It is found to be associated with Plk1 (Polo-like kinase) in a polo-box–dependent manner. Plk1 is a serine/threonine kinase that functions in cell cycle, especially in mitosis. INCEP participates in the localization of Bub1 (Budding uninhibited by benzimidazole 1), a serine/threonine kinase involved in spindle checkpoint, to kinetochore. This, in turn, promotes the recruitment of Plk1 to kinetochores. Phosphorylated INCENP stimulates the activity of Aurora B kinase at centromeres and the central spindle that is important for chromosome segregation and cytokinesis, respectively.

ANTI-INCENP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-INCENP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 13)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
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  • ANTI-INNER CENTROMERE PROTEIN
  • ANTI-INCENP
  • Anti-INCENP antibody produced in rabbit
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