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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Struktur
189028-95-3
CAS-Nr.
189028-95-3
Englisch Name:
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
Synonyma:
(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one;ZT-5;idin-2-one;Ezetimibe-003;Ezetimibe INT A;(S)-3-((S)-5-(4-FL;-5-(4-Fluorophenyl);-5-hydroxypentanoyl);)-5-hydroxypentanoyL;Ezetimibe Impurity 45
CBNumber:
CB71473325
Summenformel:
C20H20FNO4
Molgewicht:
357.38
MOL-Datei:
189028-95-3.mol

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Eigenschaften

Siedepunkt:
572.7±50.0 °C(Predicted)
Dichte
1.297
storage temp. 
2-8°C
L?slichkeit
Chloroform (Sparingly), Methanol (Slightly)
Aggregatzustand
Solid
pka
14.17±0.20(Predicted)
Farbe
White to Off-White

Sicherheit

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

Chemische Eigenschaften

Solid

Verwenden

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

Einzelnachweise

http://www.cphi-online.com/ezetimibe-intermediate-4s3-prod587443.html
https://en.wikipedia.org/wiki/2-Oxazolidone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 288)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
SyncoZymes (Shanghai) Co., Ltd.,
+86-021-68187180-811 +86-13681683526
 lchen@syncozymes.com China 188 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 18751 58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951
CHINA 115 55
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 9087 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3009 60
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58

189028-95-3()Verwandte Suche:

  • (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
  • (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one
  • (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxo-pentyl]-4-phenyl-2-Oxazolidinone
  • EzetiMibe InterMediates
  • 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- 2-Oxazolidinone
  • Ezetimibe INT A
  • ZT-5
  • 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-
  • (4S)-3-[(5R)-5-(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-pheny-1,3-oxzolidin-2-One
  • 2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)-
  • -5-(4-Fluorophenyl)
  • -5-hydroxypentanoyl)
  • (S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-2-oxazolidinone
  • Ezetimibe Impurity 45
  • Ezetimibe-003
  • Ezetimibe Impurity 51
  • 3-[5-(4-fluoro- phenyl)-5-hydroxy- pentanoyl]-5-phenyl- oxazolidin-2-one
  • 3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one
  • (S)-3-((S)-5-(4-FL
  • idin-2-one
  • )-5-hydroxypentanoyL
  • (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONEENYL-2-OXAZOLIDINONE
  • (4S)-3-[(5S)-5-(3-fluorophenyl)-5- hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
  • (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL...
  • (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
  • Ezetimibe Impuriry 51
  • Ezetimibe intermediate D
  • 189028-95-3
  • (4S)-3-[(5S)-5-(3-FLUOROPHENYL)-5-
  • 3-[(5S)-5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4(S)-phenyl-2-oxazolidinone
  • (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxyvaleryl] -4-phenyl-1,3-oxyazacyclopentane-2-one
  • (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxypentanoyl] -4-phenyl-1,3-oxazole-2-one
  • 189028-95-3
  • Ezetimibe
  • Ezetimibe intermediates
  • 189028-95-3
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