BI-2865 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signaling and proliferation was restricted to cancer cells harboring mutant KRAS, and drug treatment suppressed KRAS mutant tumor growth in mice without having a detrimental effect on animal weight.
BI-2865 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte