CIPROXIFAN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt m?glich.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Ciproxifan is a histamine H₃ receptor antagonist (K_i = 0.5 nM for inhibition of histamine release in rat synaptosomal preparations). It is selective for histamine H₃ over histamine H₁ and H₂, M₃ muscarinic, and α_1D- and β₁-adrenergic receptors (K_is = 3.15-25 μM), as well as the serotonin (5-HT) receptor subtypes 5-HT_1B, 5-HT_2A, 5-HT₃, and 5-HT₄ (K_is = 1.58-15 μM) in radioligand binding assays. Ciproxifan (3-300 nM) inhibits relaxation in precontracted isolated guinea pig ileal longitudinal muscle induced by R-(–)-α-methylhistamine . In vivo, ciproxifan reduces R-(–)-α-methylhistamine-induced water consumption in rats (ED₅₀ = 0.09 mg/kg). It increases wake episode duration and latency to fall asleep in rats when administered at a dose of 2 mg/kg.

Verwenden

Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.

Biochem/physiol Actions

Potent, selective H3 histamine receptor antagonist.

CIPROXIFAN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CIPROXIFAN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

184025-19-2()Verwandte Suche:

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• Ciproxifan Moleate
• FUB 359 Maleate
• FUB359 Maleate
• FUB-359 Maleate
• Ciproxifan maleate, >=98%
• Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt
• (4-(3-(1H-Imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate
• CIPROXIFAN
• FUB 359 maleate salt, Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt
• FUB 359 Maleate salt
• Methanone, cyclopropyl[4-[3-(1H-iMidazol-4-yl)propoxy]phenyl]-, (Z)-2-butenedioate (1:1)
• Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]methanone (2Z)-2-butenedioate
• Ciproxifan Maleate (FUB-359)
• (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
• FUB 359 MALEATE;FUB359 MALEATE;FUB-359 MALEATE
• Ciproxifan maleate(FUB-359 maleate)
• CS-109
• Inhibitor,aging,inhibit,Ciproxifan,disorders,Ciproxifan maleate,FUB359,Histamine Receptor,FUB-359,histamine,Alzheimer's
• (4-(3-(1H-Imidazol-4-yl)propoxy)phenyl)(cyclopropyl)methanone maleate
• Ciproxifan maleate, prototypic H3 inverse agonist / antagonist
• Ciproxifan maleate, 10 mM in DMSO
• 184025-19-2
• C16H18N2O2C4H4O4
• Inhibitors