B-D-GLUCOPYRANOSE
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- CAS-Nr.
- 60976-49-0
- Englisch Name:
- B-D-GLUCOPYRANOSE
- Synonyma:
- 7:4®eraniin;GERANIIN;geranicin;Geraniin-RM;B-D-GLUCOPYRANOSE;b-D-Glucopyranose, cyclic 2®3,4,4,6,7,15,16,17,18,19,20-undecahydroxy-2,9,13,22,27-penta...;Geraniin,Tumor Necrosis Factor Receptor,inhibit,TNF Receptor,Inhibitor,TNFR;5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-Methano-2H-1-benzoxocin-5,7-dicarboxylate)cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate)1-(3,4,5-trihydroxybenzoate), stereoisoMer
- CBNumber:
- CB6848749
- Summenformel:
- C41H28O27
- Molgewicht:
- 952.64
- MOL-Datei:
- 60976-49-0.mol
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B-D-GLUCOPYRANOSE Eigenschaften
- Dichte
- 2.25
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- L?slichkeit
- DMSO : 100 mg/mL (104.97 mM; Need ultrasonic)
- Aggregatzustand
- powder
- pka
- 6.35±0.70(Predicted)
- Farbe
- Light yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
B-D-GLUCOPYRANOSE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Geraniin is a tannin that has been found in
P. urinaria and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC
50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC
50 = 2.65 μM), and hydroxyl radicals (IC
50 = 1.44 μM) in cell-free assays. Geraniin inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in plaque reduction assays (IC
50s = 35 and 18.4 μM, respectively). It inhibits angiotensin-converting enzyme (ACE)
in vitro (IC
50 = 13.22 μM) and reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg. Geraniin (5, 10, and 20 μM) induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells. It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 10 and 20 mg/kg.
Verwenden
Geraniin protects PC12 cells against neuronal damage and may be used in the treatment of Alzheimer’s disease/ Also is an ACE inhibitor which is useful for hypertension treatment.
B-D-GLUCOPYRANOSE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
B-D-GLUCOPYRANOSE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 166)Lieferanten
60976-49-0()Verwandte Suche:
- eraniin
- GERANIIN
- B-D-GLUCOPYRANOSE
- beta-D-Glucopyranose cyclic 2-7:4-5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-methano-2H-1-benzoxocin-5,7-dicarboxylate) cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate) stereoisomer
- 5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-Methano-2H-1-benzoxocin-5,7-dicarboxylate)cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate)1-(3,4,5-trihydroxybenzoate), stereoisoMer
- 7:4®
- b-D-Glucopyranose, cyclic 2®
- 3,4,4,6,7,15,16,17,18,19,20-undecahydroxy-2,9,13,22,27-pentaoxo-2,3,4,4a,9,11a,13,22,24,25,25a,27-dodecahydro-11H-3,5-epoxy-25,11-(epoxymethano)dibenzo[h,j]dibenzo[7,8:9,10][1,5]dioxacycloundecino[3,2-b][1,6]dioxacyclododecin-29-yl 3,4,5-trihydroxybenzoat
- β-D-Glucopyranose, cyclic 2→7:4→5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-methano-2H-1-benzoxocin-5,7-dicarboxylate) cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), stereoisomer
- 3,4,4,6,7,15,16,17,18,19,20-undecahydroxy-2,9,13,22,27-penta...
- Geraniin,Tumor Necrosis Factor Receptor,inhibit,TNF Receptor,Inhibitor,TNFR
- geranicin
- (57R,58S,510R,511R,519S)-14,15,16,24,25,26,52,53,516,517,517-Undecahydroxy-55,513,515,3,8-pentaoxo-55,57,58,510,511,513,515,516,517,517a-decahydro-4,7-dioxa-5(19,10)-1,16-epoxy-7,11-methanodibenzo[i,k][1,4,7]trioxacyclotridecina-1,2(1,2)-dibenzenacyclooctaphane-58-yl 3,4,5-trihydroxybenzoate
- Geraniin-RM
- 60976-49-0
- C41H28O27
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract