1,2,4,5-Tetrazine, 3-[([1,1'-biphenyl]-4-ylmethyl)thio]-6-methyl- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine (
b-Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications. Tetrazines are often incorporated into chemical probes or other small-molecule tools using linkers that may impact physicochemical properties or the performance of the resulting conjugate product. Here,
Lambert et al demonstrated the linker-free incorporation of
b-Tz via silver-mediated Liebeskind-Srogl cross-coupling with a variety of aryl and heteroaryl boronic acids. This ″minimal″ tetrazine approach will facilitate the introduction of tetrazine into diverse complex molecules and improved probes for live-cell imaging and in vivo chemistry.
Supporting products
PdCl
2(dppf):
697230Ag
2O:
226831
1,2,4,5-Tetrazine, 3-[([1,1'-biphenyl]-4-ylmethyl)thio]-6-methyl- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte