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Tomatidine hydrochloride

Tomatidine hydrochloride Struktur
6192-62-7
CAS-Nr.
6192-62-7
Englisch Name:
Tomatidine hydrochloride
Synonyma:
TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;Tomatidine hydrochloride-RM;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
CBNumber:
CB6774105
Summenformel:
C27H46ClNO2
Molgewicht:
452.11
MOL-Datei:
6192-62-7.mol

Tomatidine hydrochloride Eigenschaften

Schmelzpunkt:
281-284°C (dec.)
storage temp. 
2-8°C
L?slichkeit
Methanol (Slightly)
Aggregatzustand
Off-white solid
Farbe
White to Off-White
BRN 
3920740
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Tomatidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Off-White Solid

Verwenden

Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).

Biologische Aktivit?t

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.

Mode of action

Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.

Tomatidine hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tomatidine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 110)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Chengdu Greenpure Biopharma CO.,Ltd
18283602253; +8618283602253
jancyzheng@gcgreenpure.com China 953 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15319487004
1015@dideu.com China 3209 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Aktin Chemicals, Inc.
028-85159085
info@aktinchem.com CHINA 1025 58
Wuhan Nutra Biotechnology Co.,Ltd
+8617786394783
nutrabiotech@outlook.com China 300 58

6192-62-7()Verwandte Suche:


  • 3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE
  • 5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE
  • TOMATIDINE HCL
  • TOMATIDINE HYDROCHLORIDE
  • SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
  • (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride
  • TOMATIDINE HCL(RG)
  • Tomatidine, Hydrochloride, >85%
  • ToMatidin Hydrochloride, >85%
  • 3β-Hydroxy-5α-tomatidane hydrochloride, 5α-Tomatidan-3β-ol hydrochloride
  • (3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride
  • (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride (1:1)
  • 3β-Hydroxy-5α-tomatidane hydrochloride
  • 5α-Tomatidan-3β-ol hydrochloride
  • Tomatidine, HCl - CAS 6192-62-7 - Calbiochem
  • Tomatidine Hydrochloride, >
  • 5alpha-Tomatidan-3beta-ol HCl
  • Tomatidine hydrochloride-RM
  • 6192-62-7
  • C27H46ClNO2
  • C27H45NO2HCl
  • Lipid signaling
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
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