Tomatidine hydrochloride
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- CAS-Nr.
- 6192-62-7
- Englisch Name:
- Tomatidine hydrochloride
- Synonyma:
- TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;Tomatidine hydrochloride-RM;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
- CBNumber:
- CB6774105
- Summenformel:
- C27H46ClNO2
- Molgewicht:
- 452.11
- MOL-Datei:
- 6192-62-7.mol
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Tomatidine hydrochloride Eigenschaften
- Schmelzpunkt:
- 281-284°C (dec.)
- storage temp.
- 2-8°C
- L?slichkeit
- Methanol (Slightly)
- Aggregatzustand
- Off-white solid
- Farbe
- White to Off-White
- BRN
- 3920740
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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Sicherheit |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tomatidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Off-White Solid
Verwenden
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).
Biologische Aktivit?t
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Mode of action
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Tomatidine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tomatidine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 110)Lieferanten
6192-62-7()Verwandte Suche:
- 3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE
- 5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE
- TOMATIDINE HCL
- TOMATIDINE HYDROCHLORIDE
- SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
- (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride
- TOMATIDINE HCL(RG)
- Tomatidine, Hydrochloride, >85%
- ToMatidin Hydrochloride, >85%
- 3β-Hydroxy-5α-tomatidane hydrochloride, 5α-Tomatidan-3β-ol hydrochloride
- (3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride
- (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride (1:1)
- 3β-Hydroxy-5α-tomatidane hydrochloride
- 5α-Tomatidan-3β-ol hydrochloride
- Tomatidine, HCl - CAS 6192-62-7 - Calbiochem
- Tomatidine Hydrochloride, >
- 5alpha-Tomatidan-3beta-ol HCl
- Tomatidine hydrochloride-RM
- 6192-62-7
- C27H46ClNO2
- C27H45NO2HCl
- Lipid signaling
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids