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SMCC crosslinker

SMCC crosslinker Struktur
64987-85-5
CAS-Nr.
64987-85-5
Englisch Name:
SMCC crosslinker
Synonyma:
SMCC;2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)Methyl)cyclohexanecarboxylate;NSC 344483;SMCC Crosslinker;N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC;LKA;R3-RM1;SMCC,98%;25MG/100MG/10G;N-SucciniMidyl 4-(N-MaleiMi
CBNumber:
CB6748487
Summenformel:
C16H18N2O6
Molgewicht:
334.32
MOL-Datei:
64987-85-5.mol

SMCC crosslinker Eigenschaften

Schmelzpunkt:
180-182 °C (lit.)
Siedepunkt:
501.7±42.0 °C(Predicted)
Dichte
1.42±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
chloroform: 50 mg/mL
Aggregatzustand
powder
pka
-2.24±0.20(Predicted)
Farbe
White to Off-White
Sensitive 
Moisture & Light Sensitive
BRN 
1555271
InChI
InChI=1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
InChIKey
JJAHTWIKCUJRDK-UHFFFAOYSA-N
SMILES
C1(C(ON2C(=O)CCC2=O)=O)CCC(CN2C(=O)C=CC2=O)CC1
CAS Datenbank
64987-85-5(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36-60-37
WGK Germany  3
10-21
HS Code  29280000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

SMCC crosslinker Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

SMCC crosslinker is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then can be added to an aqueous crosslinking reaction. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane and can be used to crosslink intracellular proteins and peptides.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(abTaIII)2 fragments to l-B-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms.

Definition

ChEBI: Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is an N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. It is a member of maleimides and a N-hydroxysuccinimide ester.

Allgemeine Beschreibung

4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.

Chemische Reaktivit?t

Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a non-cleavable and membrane permeable crosslinker. It contains an amine-reactive N -hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. The maleimide groups of SMCC and Sulfo-SMCC and are unusually stable up to pH 7.5 because of the cyclohexane bridge in the spacer arm.

SMCC crosslinker Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SMCC crosslinker Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 275)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangxi Huihe Chemical Co., Ltd.
+86-19189228086 +8618858568638
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ivan@atkchemical.com China 32957 60
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sales@coreychem.com China 29880 58
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+86 18953170293
sales@sdzschem.com China 2930 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830
figo.gao@foxmail.com China 8497 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887
sales@finerchem.com China 2961 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

64987-85-5()Verwandte Suche:


  • SMCC [4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester]
  • trans-4-(Maleimidomethyl)-cyclohexane carboxylic acid-NHS ester
  • N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexanecarboxylate
  • 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylic acid N-hydroxysucciniMide ester, 98+%
  • 4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester SMCC
  • 25MG/100MG/10G
  • SMCC N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate
  • N-SucciniMidyl 4-(MaleiMidoMethyl)cyclohexane-1-carboxylate(SMCC)
  • 4-(MaleiMidoMethyl)cyclohexane-1-carboxylic acid N-hydroxysucciniMide ester, 98+%
  • N-SucciniMidyl 4-(N-MaleiMi
  • SucciniMidyl-4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate (SMCC)
  • N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexanecarboxylate , 98.0%(LC)
  • N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-
  • N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate
  • 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-*
  • 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylat
  • n-(4-carboxycyclohexylmethyl)maleimiden-hydroxysuccinimideester
  • SUCCINIMIDYL TRANS-4-(MALEIMIDYLMETHYL)CYCLOHEXANE-1-CARBOXYLATE
  • SUCCINIMIDYL-TRANS-4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
  • SUCCINIMIDYL-TRANS-4-(N-MALEIMIDYLMETHYL)CYCLOHEXANE-1-CARBOXYLATE
  • SUCCINIMIDYL 4-[N-MALEIMIDO-METHYL]CYCLOHEXANE-1-CARBOXYLATE
  • N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
  • N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLATE
  • TRANS-4-(N-MALEIMIDYLMETHYL)-CYCLO-HEXANE-1-CARBOXYLATE-N-HYDROXYSUCCINIMIDE ESTER
  • 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER
  • 4-(N-MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER
  • N-succinimidyl 4-(maleimidome.)cyclo-hexanecarboxylate
  • 4-(N-MALEIMIDOMETHYL)-CYCLOHEXANE-1-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
  • N-Succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate
  • 4-(maleimidomethyl)-1-cyclohexanecarboxylic acid N-hydroxy
  • N-Succinimidyl 4-(N-maleimidomethyl)cycl
  • 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester
  • LKA
  • 4-(Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester
  • trans-4-(Maleimidomethyl)-cyclohexane carboxylic
  • SMCC [4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester] *CAS 64987-85-5*
  • N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate >
  • Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester
  • Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate
  • N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (2mg*5)
  • 4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester
  • 2,5-Dioxopyrrolidin-1-yl 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexane-1-carboxylate
  • R3-RM1
  • Succinimidyl-4-(N- (N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC), 98%
  • (2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate
  • N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC
  • 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)Methyl)cyclohexanecarboxylate
  • SMCC Crosslinker
  • SMCC
  • NSC 344483
  • SMCC,98%
  • 4-(N-maleimidyl methyl) cyclohexane-1-carboxylic acid succinimide ester
  • N-Succinimidyl-4-[2-(4,4-Dimethoxytrityl)]Butyrate
  • SMCC, heterobifunctional cross-linker
  • 64987-85-5
  • C16H18N2O6
  • BioChemical
  • Protein Modification
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