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2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Struktur
108605-62-5
CAS-Nr.
108605-62-5
Englisch Name:
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
Synonyma:
Su 20;CS-862;Aubagio;Aids013145;Aids-013145;rac-A77 1626;Teriflunomide;(E/Z)-Teriflunomide;TeriflunoMide, A77 1726;Teriflunomide((E/Z) Mixture)
CBNumber:
CB6464433
Summenformel:
C12H9F3N2O2
Molgewicht:
270.21
MOL-Datei:
108605-62-5.mol

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Eigenschaften

Schmelzpunkt:
229-232°C
Siedepunkt:
410.8±45.0 °C(Predicted)
Dichte
1.424±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Aggregatzustand
Solid
pka
5.20±0.50(Predicted)
Farbe
White
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
HS Code  2926900005
Toxizit?t mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),United States Patent Document. Vol. #5494911,
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Teriflunomide (Aubagio®), also known as A77 1726, is an immunosupressant marketed by Sanofi for the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced B and T cell proliferation.

Chemische Eigenschaften

White Solid

Verwenden

The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 170)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683
mcbio_sales@163.com China 2251 58

108605-62-5()Verwandte Suche:


  • N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M
  • (2Z)-2-[hydroxy-[[4-(trifluoromethyl)phenyl]amino]methylidene]-3-oxo-butanenitrile
  • 2-Cyano-3OH-N-(4-trifluoromethylphenyl) crotonamide-d4
  • IMp. A (EP) as Hydrochloride: 4-(TrifluoroMethyl)aniline Hydrochloride
  • TeriflunoMide, A77 1726
  • 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide
  • 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
  • 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
  • (E)-2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)-2-butenamide
  • 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-
  • Aids013145
  • Aids-013145
  • Su 20
  • Teriflunomide
  • (Z)-2-cyano-3-hydroxy-N-(4-(trifluoroMethyl)phenyl)but-2-enaMide
  • Leflunomide Related Compound B (10 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide)
  • 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide
  • Leflunomide Related Compound B (20 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide)
  • 2-cyano-3-hydroxy-n-(4-(trifluoromethyl)phenyl)-2-butenamid
  • n-(4-trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide
  • N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTOAMIDE
  • N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTONAMIDE
  • 2-CYANO-3-OH-N-(4-TRIFLUOROMETHYLPHENYL) CROTONAMIDE
  • 2-CYANO-3-HYDROXY-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-BUTENAMIDE
  • Teriflunomide(Random Configuration)
  • (2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxobutanenitrile
  • Leflunomide ImpuritⅡ: 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
  • CS-862
  • 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)cro
  • rac-A77 1626
  • Leflunomide impurityⅡ[2-cyano-3-hydroxy-N-(4’-trifluoromethylphenyl)-crotone amide]
  • Aubagio
  • 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide USP/EP/BP
  • Teriflunomide((E/Z) Mixture)
  • Leflunomide USP Related Compound B
  • Leflunomide ImpuritⅡ: 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
  • Leflunomide Related Compound B (2-Cyano-3-hydroxy-N-(4''-trifluoromethylphenyl)-crotone amide) (1357056)
  • Leflunomide impurityⅡ [2-cyano-3-hydroxy-N-(4’ -trifluoromethylphenyl)-croton e amide
  • (E/Z)-Teriflunomide
  • 2-cyano-3-hydroxy-crotonic acid 4-trifluoro-methyl-anilide
  • 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
  • 108605-62-5
  • C12H5F3N2O2D4
  • Various Metabolites and Impurities
  • Metabolites & Impurities
  • Tyrosine Kinase Inhibitors
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