3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials.

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19904	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24973	58
StressMarq Biosciences Inc	1250-294-9065	info@stressmarq.com	China	3181	58
Merck KGaA	21-20338288	ordercn@merckgroup.com	China	6394	58
Biosynth Biological Technology (Suzhou) Co Ltd	51288865780	sales@biosynth.com	China	6051	58
Hangzhou Haofeng Biotechnology Co., Ltd.	057186405477		CHINA	0	58

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• 3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone
• YM-08
• 4-Thiazolidinone, 3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-
• YM-08, blood-brain barrier permeable Hsp70 inhibitor
• 812647-88-4