Grape Seed Extract
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- CAS-Nr.
- 84929-27-1
- Englisch Name:
- Grape Seed Extract
- Synonyma:
- Proanthocyanidin;GSE;GRAPE SEED;Vitis vinifera leaf extract;VITIS VINIFERA (GRAPE) LEAF EXTRACT;Grape skin;NataPres GS;Grape seed dry;Unii-T3pw93ib4q;Grape, red, ext.
- CBNumber:
- CB6258001
- Summenformel:
- C32H30O11
- Molgewicht:
- 590.574
- MOL-Datei:
- 84929-27-1.mol
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Grape Seed Extract Eigenschaften
- Dichte
- 0.961g/cm3 at 20℃
- Dampfdruck
- 0.003Pa at 60℃
- FEMA
- 4045 | GRAPE SEED EXTRACT
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Solid:particulate/powder
- Farbe
- Brown to reddish brown
- InChIKey
- VWKAFYWVDIOMSL-PSXRJWADNA-N
- SMILES
- [C@H]1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O)=C2)[C@@H](C2C3O[C@H](C4=CC=C(O)C(O)=C4)[C@@](O)(C)CC=3C(C)=CC=2O)[C@@H]1O |&1:0,18,22,31,41,r|
- LogP
- 6.5 at 25℃ and pH5-6
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P233 |
Beh?lter dicht verschlossen halten. |
| P240 |
Beh?lter und zu befüllende Anlage erden. |
| P241 |
Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Ger?te verwenden. |
| P242 |
Nur funkenfreies Werkzeug verwenden. |
| P243 |
Ma?nahmen gegen elektrostatische Entladungen treffen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P370+P378 |
Bei Brand: zum L?schen verwenden. |
| P403+P235 |
An einem gut belüfteten Ort aufbewahren. Kühl halten. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Grape Seed Extract Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Grape seed extract has an astrigent taste.
Occurrence
Grapeseed is found throughout the world.
Verwenden
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.
Anticancer Research
Grape seed extract (GSE) has high quantities of proanthocyanidins and resveratrol.Human colorectal cancer cell (CRC) exposure to GSE (Schonthal 2012) resulted inmodified ER chaperones glucose-related protein-78 (GRP78) and protein disulphideisomerase (PDI). GRP78 is needed for integrity of ER as well as stress-inducedautophagy (Flaumenhaft et al. 2015). PDI, a thiol-disulphide oxidoreductase,catalyses the disulphide bonds in newly synthesized proteins in the ER lumen (Hanet al. 2013; Wang and Kaufman 2014; Perri et al. 2016), and PDIA3 is localized tothe ER and is involved in protein folding (Wang et al. 2012b). Studies on the role ofPDI in cancer have demonstrated a pro-oncogenic, pro-survival role for PDI incancer and therapeutic resistance. PDI aids in ameliorating stress-induced apoptosisand causes degradation of wrongly folded proteins (Dinicola et al. 2010; Xu et al.2014). Hence, any obstruction caused in the activity of PDI will induce stress in thecell and lead to cell apoptosis. Fructose bisphosphate aldolase, a key enzymeinvolved in glycolysis, is also a potential target of GSE (Vandewynckel et al. 2016).The ER stress leads the cell to undergo apoptotic pathways in multiple ways andhence inhibits the proliferation of the targeted cells (Farooqi et al. 2015).
Sicherheit(Safety)
Grape seed extract is generally well tolerated when taken in moderate amounts. It has been tested safely for up to 11 months in human studies. It’s possibly unsafe if you have a bleeding disorder or are going to have surgery or if you take anticoagulants (blood thinners), such as warfarin or aspirin. Little is known about whether it’s safe to use grape seed extract during pregnancy or while breastfeeding.
Grape Seed Extract Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Grape Seed Extract Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 374)Lieferanten
84929-27-1()Verwandte Suche:
- Extract of grape leaf
- Unii-T3pw93ib4q
- Vitis vinifera L. (vitaceae), extract
- Grape Seed Extract, 95 Percent, Powder
- GRAPE SEED EXTRACT
- Grape seed dry
- Grape skin
- Grape, red, ext.
- VITIS VINIFERA (GRAPE) FRUIT EXTRACT
- Q435 Grape seed extract
- NataPres GS
- Einecs 284-511-6
- TANAL WG (GRAPESEED EXTRACT WG)
- Grapeseedextractdry/Proanthocyanidins&polyphenols
- GrapeseedP.E.exvitisvinifera
- GrapepeelextractexVitisvinifera
- GRAPESEED EXTRACT (EUROPEAN) OMNIVIN R
- GRAPESEED EXTRACT 95% GAE
- GRAPELEAFEXTRACT
- Broccoli flower extract
- VITIS VINIFERA (GRAPE) ROOT EXTRACT
- Grape Seed Extract USP/EP/BP
- Grape Seed Extract (Technical Grade)
- red vitis vinifera juice extract
- red vitis vinifera fruit extract
- white vitis vinifera fruit extract
- Grape Seeds Extract (OPC 95%)
- Vitis vinifera leaf extract
- GRAPE SEED
- GSE
- Proanthocyanidin
- VITIS VINIFERA (GRAPE) LEAF EXTRACT
- Grape Seed Extract OPC
- Vitis vinifera ext
- Grape Fruit Water
- 84929-27-1
- C30H12O6
- Inhibitors
- Natural Plant Extract
- Plant extracts
