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(S)-Ketorolac

(S)-Ketorolac Struktur
66635-92-5
CAS-Nr.
66635-92-5
Englisch Name:
(S)-Ketorolac
Synonyma:
Ketorolac S-IsoMer;(S)-Ketorolac ISO 9001:2015 REACH;Ketorolac impurity 2/Ketorolac S-Isomer;Phosphorousacid,tris(1,5-dimethylethyl)ester;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
CBNumber:
CB62485724
Summenformel:
C15H13NO3
Molgewicht:
255.27
MOL-Datei:
66635-92-5.mol

(S)-Ketorolac Eigenschaften

Schmelzpunkt:
160-167?C
Siedepunkt:
493.2±40.0 °C(Predicted)
Dichte
1.33±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
L?slichkeit
Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly
Aggregatzustand
A crystalline solid
pka
4.29±0.20(Predicted)
Farbe
White to off-white
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

(S)-Ketorolac Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.

Chemische Eigenschaften

Off-White Solid

Verwenden

(S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Definition

ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

(S)-Ketorolac Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(S)-Ketorolac Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 64)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
CR Corporation Limited
+8613062833949
fred.wen@crcorporation.cn China 8647 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Hebei Miaoyin Technology Co.,Ltd
+86-17367732028 +86-17367732028
kathy@hbyinsheng.com China 3512 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11922 58

  • Ketorolac S-IsoMer
  • Ketorolac impurity 2/Ketorolac S-Isomer
  • 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
  • (S)-Ketorolac ISO 9001:2015 REACH
  • Phosphorousacid,tris(1,5-dimethylethyl)ester
  • 66635-92-5
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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