Riociguat
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- CAS-Nr.
- 625115-55-1
- Englisch Name:
- Riociguat
- Synonyma:
- CS-718;Aratac;Riocguat;riocigua;Leosigua;Riociguat;Riociguatr;Bay 63-2521;Amiodaronum;Riociguat (250 mg)
- CBNumber:
- CB62473752
- Summenformel:
- C20H19FN8O2
- Molgewicht:
- 422.42
- MOL-Datei:
- 625115-55-1.mol
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Riociguat Eigenschaften
- Schmelzpunkt:
- 247-251°C (dec.)
- Siedepunkt:
- 567.2±50.0 °C(Predicted)
- Dichte
- 1.51
- storage temp.
- Refrigerator
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 1.51±0.50(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Orange
- InChI
- InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
- InChIKey
- WXXSNCNJFUAIDG-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)N(C1=C(N)N=C(C2C3=CC=CN=C3N(CC3=CC=CC=C3F)N=2)N=C1N)C
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Riociguat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In September 2013, Health Canada approved riociguat (also referred to as BAY 63-2521), for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) after surgical treatment or inoperable CTEPH and for the treatment of adults with pulmonary arterial hypertension (PAH). Riociguat has a dual mode of action and works by (a) sensitizing sGC to the body’s NO by stabilizing NO–sGC binding and (b) an NO-independent, direct stimulation of sGC via a different binding site. This process restores the NO–sGC–cGMP pathway and leads to increased generation of cGMP with subsequent vasodilation.
Headache, dizziness, dyspepsia/gastritis, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation were the most common adverse events ( 3%) observed during riociguat clinical trials. Riociguat comes with a black box warning for embryo-fetal toxicity.
Chemische Eigenschaften
Brownish Orange Solid
Verwenden
Riociguat is used in the treatment for pulmonary hypertension.
Definition
ChEBI: A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension an
pulmonary arterial hypertension
Riociguat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Riociguat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 330)Lieferanten
- Riociguat
- N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
- Bay 63-2521
- Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-B)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester
- Riociguat (BAY 63-2521)
- Bay63-2521,Riociguat
- [4,6-DiaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]MethylcarbaMic acid Methyl ester
- Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate
- Riociguat N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
- Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-, methyl ester
- fondaparinux sodium intermediateA-8)
- Riocguat
- CS-718
- Riociguat, BZY 632521
- BAY 63-2521; BAY 632521
- Riociguat IMpurtiy D
- methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
- riocigua
- Riociguat USP/EP/BP
- Riociguatr
- [4,6-Diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin...
- Riociguat 13CD3Q: What is
Riociguat 13CD3 Q: What is the CAS Number of
Riociguat 13CD3 Q: What is the storage condition of
Riociguat 13CD3 Q: What are the applications of
Riociguat 13CD3
- Amiodaronum
- Aratac
- Leosigua
- Riociguat (250 mg)
- 625115-55-1
- 615115-55-1
- C20H19FN8O2
- API
