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Dihydroergotoxine mesylate

Dihydroergotoxine mesylate Struktur
8067-24-1
CAS-Nr.
8067-24-1
Englisch Name:
Dihydroergotoxine mesylate
Synonyma:
ERGOLOID MESYLATES;hydergine;circanol;Epos;ergoloid mesylate;cck179;Decril;Trigot;Inorter;Dacoren
CBNumber:
CB6226235
Summenformel:
C20H29N3O5S
Molgewicht:
423.53
MOL-Datei:
8067-24-1.mol

Dihydroergotoxine mesylate Eigenschaften

storage temp. 
Store at RT
L?slichkeit
DMSO: Slightly Soluble; Methanol: 1 mg/ml
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
ONYMVHQTXOEAOV-TZWRWDCZNA-N
SMILES
C12C3=CC=CC=1[C@@]1([H])C[C@H](CN(C)[C@]1([H])CC2=CN3)C(=O)N[C@@H](C)CO.S(=O)(=O)(O)C |&1:6,9,13,22,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60
S-S?tze: 53-36/37/39-45
RIDADR  1544
RTECS-Nr. KE8800000
HazardClass  6.1(b)
PackingGroup  III
HS Code  3003490000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Dihydroergotoxine mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Ergoloid, also known as dihydroergotoxine mesylate, is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.

Verwenden

Cognition adjuvant. Dihydroergotoxine mesylate binds with high affinity to GABAA receptor Cl- channel. Interacts with central dopaminergic, serotonergic and adrenergic (a1) receptors. Exhibits antirproliferative activity in vitro. Displays cognition-enhancing, anticonvulsant and sedative activity in vivo. Dihydroergotoxine mesylate is a substrate of GABA Receptor.

Definition

ChEBI: Dihydroergotoxine mesylate is a mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroer ocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.

Biologische Aktivit?t

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts. Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo. 

Dihydroergotoxine mesylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dihydroergotoxine mesylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 142)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533
Ethan@dornechem.com China 3097 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58

8067-24-1()Verwandte Suche:


  • cck179
  • co-dergocrinemesylate
  • dihydroergotoxinemesilate
  • dihydroergotoxinemethanesulfonate
  • dihydroergotoxinemethanesulphonate
  • dihydroergotoxinemonomethanesulfonate(salt)
  • dihydroergotoxinmesylate
  • dihydroergotoxinmethanesulfonate
  • dihydro-ergotoxinmethanesulfonate
  • dihydro-ergotoxinmonomethanesulfonate(salt)
  • hydergin
  • ischelium
  • redergin
  • DIHYDROERGOTOXINE MESYLATE
  • DIHYDROERGOTOXINE MONOMETHANESULFONATE
  • Dihydroxy Ergotoxin mesylate
  • dihydroergotoxine monomethanesulphonate
  • Ergoloid Mesylates (Dihydroergotoxine Mesilate)
  • Dihydroergotoxin mesylate salt
  • Ergoloid mesylate salt
  • Inorter
  • Ergoloid Mesylates (300 mg)
  • ERGOLOIDMESYLATES,USP
  • Co-dercrine mesylate
  • Codergine mesylate
  • Codergocrine methanesulfonate
  • Coristin
  • Dacoren
  • Deapril ST
  • Decril
  • Dulcion
  • Ergodesit
  • Ergohydrin
  • Ergoplus
  • Ergotoxine, dihydro-, monomethanesulfonate (salt)
  • Hydergine (8CI)
  • Novofluen
  • Perenan
  • Progeril
  • Sponsin
  • Trigot
  • DihydroergotoxinMesilat
  • Co-dergocrine
  • Dihydroergotoxine Mesilate RS
  • Codergocrine mesilate CRS
  • Dihydro-ergotoxine Methanesulfonate (1.0mg/ml in DMSO)
  • Dihydroergotoxine mesylate 8067-24-1
  • Ergoloid Mesylates (1239504)
  • circanol
  • Epos
  • ergoloid mesylate
  • ERGOLOID MESYLATES
  • hydergine
  • amixtureof: —(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-10b-hydroxy-2,5-bis(1-methylethyl)-3,6-dioxooctahydro-8h-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamidemethanesulfonate(dihydroergocorninemesilate)
  • Cocaine Hydrochloride Impurity 2(Cocaine Hydrochloride EP Impurity B )(α-Truxilline)
  • 8067-24-1
  • C29H38N5O8SR
  • C19H25N3O2CH4O3S
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