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Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21

Anti-KREV-1,  Anti-KREV1,  Anti-RAP1,  Anti-SMGP21 Struktur
CAS-Nr.
Englisch Name:
Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21
Synonyma:
Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21;Monoclonal Anti-RAP1 A/B antibody produced in mouse
CBNumber:
CB62102469
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21 Eigenschaften

storage temp. 
−20°C

Sicherheit

Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-RAP1 A/B antibody produced in mouse may be used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry

Allgemeine Beschreibung

Monoclonal Anti-RAP1 A/B (mouse IgM isotype) is derived from the hybridoma R116 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice. Ras-related protein 1A (RAP1A/Krev-1) belongs to the Ras superfamily of small GTPases. RAP1 gene is mapped to human chromosome 1p13.3

Biochem/physiol Actions

Ras-related protein 1A (RAP1A), a novel oncoprotein in human malignancies acts as an important modulator in T cell response. RAP1A also participates in bacterial infection, cell dynamics and osteoblast differentiation. It may serve as a Ras antagonist and is a tumor suppressor gene. RAP1A is activated by growth factors, neurotransmitters and cytokines. Several second messengers, such as cyclic adenosine monophosphate (cAMP), diacylglycerol and calcium may serve as the mediators of this activation. In many cells, active RAP1 changes its cellular location from endosomal membranes to the plasma membrane. RAP1 binds competitively to RAS-GTPase activating protein (RASA) thus interfering with its RAS effectors functions. Ectopically expressed RAP1 is capable of interacting with the RAS effector (RAF1), which may lead to the inhibition of extra-cellular-signal-regulated kinase (ERK) activation. RAP1 can also mediate cyclic adenosine monophosphate (cAMP)-induced ERK activation.

Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80

  • Anti-KREV-1, Anti-KREV1, Anti-RAP1, Anti-SMGP21
  • Monoclonal Anti-RAP1 A/B antibody produced in mouse
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