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Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2

Anti-β-Adrenergic  receptor  kinase-1,  Anti-β-ARK1,  Anti-ADRBK1,  Anti-BARK1,  Anti-G  Protein-dependent  receptor  kinase  2 Struktur
CAS-Nr.
Englisch Name:
Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2
Synonyma:
Anti-GRK2 antibody produced in rabbit;Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2
CBNumber:
CB62098939
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2 Eigenschaften

storage temp. 
−20°C

Sicherheit

Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-GRK2 antibody is suitable for western blots of cortical synaptoneurosomes to study the β-arrestin-1 and ERK protein expression. It is also suitable for western blot at a concentration of 0.5-1μg/mL using HEK-293T cells expressing human GRK2 or Jurkat cell lysate.

Allgemeine Beschreibung

G protein-coupled receptor kinases (GRK2) belongs to the GRK family that includes seven known GRKs, termed as GRK1-7. It is also known as β-adrenergic receptor kinase-1 (β-ARK1) and ADRBK1. It regulates the activity of G protein-coupled receptors (GPCRs). GRKs facilitate the uncoupling of GPCRs from G proteins, and participate directly in receptor endocytosis and trafficking, and modulation of ERK/MAPK cascade by GPCRs. It phosphorylates the activated form of the β2-adrenergic receptor (β2-AR) and related GPCRs. The GRK2 activity is regulated by different mechanisms including phosphorylation by kinases such as PKC, Src, ERK1/2 and p38MAPK. Phosphorylated ERK inactivates GRK2 on Ser670 in a negative feedback mechanism.

Biochem/physiol Actions

G protein-coupled receptor kinase 2 (GRK2) is involved in the pathogenesis of chronic heart failure.

Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80

  • Anti-GRK2 antibody produced in rabbit
  • Anti-β-Adrenergic receptor kinase-1, Anti-β-ARK1, Anti-ADRBK1, Anti-BARK1, Anti-G Protein-dependent receptor kinase 2
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