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Reversan

Reversan Struktur
313397-13-6
CAS-Nr.
313397-13-6
Englisch Name:
Reversan
Synonyma:
CBLC4H10;Reversan;N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-;5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide;ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
CBNumber:
CB61883226
Summenformel:
C26H27N5O2
Molgewicht:
441.52
MOL-Datei:
313397-13-6.mol

Reversan Eigenschaften

Schmelzpunkt:
176-180°C
Dichte
1.26±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
DMSO: ≥8mg/mL at ~60°C
pka
11.33±0.46(Predicted)
Aggregatzustand
powder
Farbe
faint yellow to yellow

Sicherheit

WGK Germany  3

Reversan Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma.

Biologische Aktivit?t

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.

Reversan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Reversan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 50)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-18791163155 +86-13119157289
 13119157289@163.com China 2973 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 4963 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136
 Sales@ATKchemical.com China 7295 58
  • N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
  • Reversan
  • CBLC4H10
  • 5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide
  • Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-
  • ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
  • 313397-13-6
  • C26H27N5O2
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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