Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
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- CAS-Nr.
- 28002-18-8
- Bezeichnung:
- Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
- Englisch Name:
- Sulbenicillin sodium
- Synonyma:
- sulpelin;kedacillin;lilacillin;sulfocillin;a-Sulfocillin;SULBENICILLIN SODIUM;sulfobenzylpenicillin;sulbenicillindisodium;disodiumsulbenicillin;Sulfonpicillin sodium
- CBNumber:
- CB6145730
- Summenformel:
- C16H16N2Na2O7S2
- Molgewicht:
- 458.42
- MOL-Datei:
- 28002-18-8.mol
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Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat Eigenschaften
- storage temp.
- Inert atmosphere,Room Temperature
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Wasserl?slichkeit
- Water: 250 mg/mL (545.35 mM)
- CAS Datenbank
- 28002-18-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Lillacillin,Takeda,Japan,1973
Manufacturing Process
To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts
by volume of water is added 1.48 parts by weight of sodium bicarbonate.
After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually
added thereto. The mixture is stirred at a temperature in the neighborhood of
0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of
portions of ether and adjusted to pH 1.2 with cation exchange resin of
polystyrene sulfonic acid type under constant cooling. Then the solution is
washed twice with 15 parts by volume of portions of ethyl acetate, followed
by extraction twice with 15 parts by volume of portions of n-butanol. The
extracts are combined and washed twice with 15 parts by volume of portions
of water and, then, extracted with an aqueous solution of sodium bicarbonate.
The extract is adjusted to pH 6.5, washed with ether and lyophilized to give
the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.
Therapeutic Function
Antibacterial
Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 175)Lieferanten
28002-18-8(Dinatrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylsulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat)Verwandte Suche:
Carbenicillin
6-(2-Phenylacetamido)penicillansure
Natriumcarbonat
Natriumgluconat
Natrium-[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz
Dimethylphthalat
Dimethyl ether
Bensulfuron methyl
Dimethylfumarat
Dimethylsulfid
Dinatrium-[2S-(2α,5α,6β)]-6-(carboxylatophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
Natriumhydroxid
N,N-Dimethylacetamid
Natriumformiat
Natriumchlorid
Poly(dimethylsiloxane)
Natriumhydrogencarbonat
- sulbenicillindisodium
- sulfobenzylpenicillin
- sulfocillin
- alpha-sulfobenzylpenicillindisodium
- sulpelin
- SULBENICILLIN DISODIUM SALT
- SULBENICILLIN SODIUM
- disodium (2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(r)-2-phenyl-2-sulfonatoacetamido]-4-thia-azabicyclo[3.2.0]heptane-2-carboxylate
- disodium [2S-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylsulphonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-, disodium salt (8CI)
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, (2S,5R,6R)- (9CI)
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, [2S-(2a,5a,6b)]-
- a-Sulfobenzylpenicillin disodium salt
- a-Sulfobenzylpenicillin sodium salt
- a-Sulfocillin
- (2S,5β)-3,3-Dimethyl-7-oxo-6α-[(R)-2-phenyl-2-sulfoacetylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid disodium salt
- 6α-[(R)-Phenyl(sodiooxysulfonyl)acetylamino]penicillanic acid sodium salt
- Sulbenicillin sodiuM Sterile
- disodiumalpha-sulfobenzylpenicillin
- disodiumsulbenicillin
- disodiumsulfobenzylpenicillin
- kedacillin
- lilacillin
- Sulbenicillin (Kedacillin, Sulfocillin)
- (2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
- Ticarcillin Sodium and Potassium Clavulanate
- Sulbenicillin Disodium Salt (Mixture of Diastereomers)
- Sulbenicillin sodium USP/EP/BP
- Sodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- Sulfonpicillin sodium
- Sulfobenzillin sodium
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt,(2S,5R,6R)-
- 28002-18-8
- C17H19N2Na2O7S
- C16H16N2NaO7S2
- C16H16N2Na2O7S2
- antibiotic
- API
- 28002-18-8
