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Olesoxime

Olesoxime Struktur
22033-87-0
CAS-Nr.
22033-87-0
Englisch Name:
Olesoxime
Synonyma:
TRO19266;NSC 21311;olesoxime;TRO 19622;Olesoxime (TRO-19622);Cholest-4-en-3-one oxime;OLESOXIME;NSC 21311;TRO19622;TRO-19622;Cholest-4-en-3-one, oxime, NSC 21311;Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism;(NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
CBNumber:
CB61254361
Summenformel:
C27H45NO
Molgewicht:
399.65
MOL-Datei:
22033-87-0.mol

Olesoxime Eigenschaften

Schmelzpunkt:
145-148 ºC
Siedepunkt:
510.0±23.0 °C(Predicted)
Dichte
1.10
storage temp. 
-20°C
L?slichkeit
DMSO: >10mg/mL
pka
12.27±0.70(Predicted)
Aggregatzustand
solid
Farbe
white
Stabilit?t:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS Datenbank
22033-87-0(CAS DataBase Reference)

Sicherheit

WGK Germany  3

Olesoxime Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

TRO 19622 interacts with mitochondria proteins and is able to promote neuron survival under stress conditions. It is a potential drug for treating amyotrophic lateral sclerosis (ALS). TRO 19622 is a neuroregenerative and neuroprotective agent. This is a research product for neuroscience.

Biologische Aktivit?t

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo . Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein.

Biochem/physiol Actions

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.

Olesoxime Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Olesoxime Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24727 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580
 cooperation@kean-chem.com China 40066 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32343 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69

22033-87-0()Verwandte Suche:

  • (NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
  • olesoxime
  • Cholest-4-en-3-one, oxime, NSC 21311
  • TRO 19622
  • Cholest-4-en-3-one oxime
  • NSC 21311
  • TRO19266
  • OLESOXIME;NSC 21311;TRO19622;TRO-19622
  • (8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-((r)-6-methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime
  • Olesoxime (TRO-19622)
  • Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism
  • (8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one oxime
  • 22033-87-0
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