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Silibinin

Silybin Struktur
22888-70-6
CAS-Nr.
22888-70-6
Bezeichnung:
Silibinin
Englisch Name:
Silybin
Synonyma:
SILYMARIN;SILYBIN;SILYBIN A;Silybin(Silibinin);Sylibin;ybin;7c3mt;Mepasil;Realsil;silybine
CBNumber:
CB6112194
Summenformel:
C25H22O10
Molgewicht:
482.44
MOL-Datei:
22888-70-6.mol

Silibinin Eigenschaften

Schmelzpunkt:
164-174°C
Siedepunkt:
793.0±60.0 °C(Predicted)
alpha 
D20 +11° (c = 0.25 in acetone + alcohol)
Dichte
1.527±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Acetone (Sparingly), DMSO, Methano (Sparingly)
Aggregatzustand
Solid
pka
pKa 6.42±0.04 (Uncertain)
Farbe
Pale Yellow
Wasserl?slichkeit
54mg/L(24.99 ºC)
Merck 
13,8607
Stabilit?t:
Stable. Incompatible with strong oxidizing agents, strong bases.
LogP
4.232 (est)
CAS Datenbank
22888-70-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-37/39-24/25-22-36
RIDADR  3172
WGK Germany  3
RTECS-Nr. DJ2981770
HS Code  29329990
Toxizit?t LD50 intravenous in mouse: 1056mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Silibinin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Silybin, also known as silibinin, is the principal biologically active constituent of the silymarin complex (about 70–80%) and is a mixture of silybin A and silybin B. Pharmacological research demonstrated that silybin has shown pleiotropic biological properties, including potent antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial and immunosuppressive activities. Silibinin demonstrates promising anticancer effects in vitro and in vivo[1].
Silybin

Chemische Eigenschaften

solid

Verwenden

Silibinin has been used:
  • to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR)
  • to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay
  • to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing
  • to study its inhibitory effect on Escherichia coli ATP synthase

Definition

ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.

Allgemeine Beschreibung

Silibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L).

Silibinin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Silibinin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 576)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
ZhenYiBio Technology Inc
+8615309206328
alexxue@zhenyibio.com China 296 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Aurora Industry Co., Ltd.
+86-13591747876 +86-13591747876
alex1_auco@126.com China 299 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58

22888-70-6(Silibinin)Verwandte Suche:


  • Silybin-A ,98%
  • Silybin (50 mg)
  • Silybin, 2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin
  • Silybin,Silymarin
  • (2R)-2α-[[(2R,3R)-2,3-Dihydro-3β-(4-hydroxy-3-methoxyphenyl)-2α-(hydroxymethyl)-1,4-benzodioxin]-6-yl]-2,3-dihydro-3β,5,7-trihydroxy-4H-1-benzopyran-4-one
  • (2R,3R)-2-[[(2R,3R)-2,3-Dihydro-3β-(4-hydroxy-3-methoxyphenyl)-2α-(hydroxymethyl)-1,4-benzodioxin]-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • Flavobion
  • silliver
  • silybine
  • silymarinei
  • silymaringroup
  • Silymrin
  • (2R,3R)-3,5,7-TRIHYDROXY-2-[(2R,3R)-3-(4-HYDROXY-3-METHOXY-PHENYL)-2-HYDROXYMETHYL-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL]-CHROMAN-4-ONE
  • Silibinin (Silybin)
  • 2-[2R,3R-DIHYDRO-3-(4-HYDROXY-3-METHOXYPHENYL)-2-(HYDROXYMETHYL)-1,4-BENZODIOXIN-6-YL]-2R,3R-DIHYDRO-3,5,7-TRIHYDROXY-4H-1-BENZOPYRAN-4-ONE
  • 2,3-DIHYDRO-3-(4-HYDROXY-3-METHOXYPHENYL)-2-(HYDROXYMETHYL)-6-(3,5,7-TRIHYDROXY-4-OXOBENZOPYRAN-2-YL)BENZODIOXINE
  • Silybin(Mixture A&B)
  • Silibinin A
  • Silybin b1
  • SilybuM substance E6
  • SilyMarin MZ 80
  • (2R,3R)-3,5,7-trihydroxy-2-((2S,3S)-3-(4-hydroxy-3-Methoxyphenyl)-2-(hydroxyMethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroMan-4-one
  • Silibinin, froM SilybuM MarianuM
  • SILYBIN (A AND B)
  • SILYMARIN I
  • SILYBININ
  • SILYBIN (MIX)
  • SILIBININ
  • PRINCIPAL COMPONENT OF SILYMARINE
  • SILYBIN (SYN. SILYMARIN)
  • MILK THISTLE EXTRACT 80%
  • 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin
  • -2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-3,5,7-trihydroxy-,(2r-(2-alpha,3-bet
  • 3r*)))-6(2r*
  • 7c3mt
  • flavobin
  • flavobinspofa
  • 2,3-DIHYDRO-3-[4-HYDROXY-3-METHOXYPHENYL]-2-[HYDROXYMETHYL]-6-[3,5,7-TRIHYDROXY-4-OXOBENZOPYRAN-2-YL]BENZODIOXIN
  • 4H-1-BENZOPYRAN-4-ONE, 2-[(2R,3R)-2,3-DIHYDRO-3-(4-HYDROXY-3-METHOXYPHENYL)-2-(HYDROXYMETHYL)-1,4-BENZODIOXIN-6-YL]-2,3-DIHYDRO-3,5,7-TRIHYDROXY-, (2R,3R)-
  • 4H-1-Benzopyran-4-one,2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,[2R-[2α,3β,6(2R*,3R*)]]-
  • Silybin ,98%
  • (3S)-3,5,7-trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one
  • Soluble SILYBIN, Liposomal SILYBIN, SILYBIN NanoEmulsion, NanoActive SILYBIN
  • Silibinin(A+B)
  • Silibinin 22888-70-6
  • 22888-70-6 Silibinin
  • Silymarin (Silibinin)
  • Silibinin, 98%, from Silybum marianum
  • (2R,3R)-3,5,7-Trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
  • Silymarin 20
  • Silybin (Mixture of Silybin A and B
  • Mepasil
  • Realsil
  • ybin
  • SILIBININ (LEGALON-SIL)
  • Silibinin USP/EP/BP
  • silliness
  • Silibinin, ≥98% (HPLC)
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