Triethylcitrat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
?LIGE FARBLOSE FLüSSIGKEIT.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation des Aerosols und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt eine gesundheitssch?dliche Kontamination der Luft nicht oder nur sehr langsam ein.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Flüssigkeit reizt die Augenund die Atemwege.
LECKAGE
Ausgelaufene Flüssigkeit in abdichtbaren Beh?ltern sammeln. Reste mit viel Wasser wegspülen.
S-S?tze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Triethyl citrate is a clear, viscous, odorless, and practically colorless,
hygroscopic liquid.
Occurrence
Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white
wine.
Verwenden
Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu-
ble in water. it is found in lemon drinks.
Vorbereitung Methode
Triethyl citrate is prepared by the esterification of citric acid and
ethanol in the presence of a catalyst.
synthetische
By esterification of ethyl alcohol with citric acid.
Allgemeine Beschreibung
Triethyl citrate is a safe direct food additive.
Pharmazeutische Anwendungen
Triethyl citrate and the related esters acetyltriethyl citrate, tributyl
citrate, and acetyltributyl citrate are used to plasticize polymers in
formulated pharmaceutical coatings. The coating applications
include capsules, tablets, beads, and granules for taste masking,
immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring,
for solvency, and as a surface active agent.
Sicherheitsprofil
Moderately toxic by
intraperitoneal route. Mildly toxic by
ingestion and inhalation. Combustible liquid
when exposed to heat or flame. To fight
fire, use dry chemical, CO2. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ESTERS and
CITRIC ACID.
Sicherheit(Safety)
Triethyl citrate is used in oral pharmaceutical formulations and as a
direct food additive. It is generally regarded as a nontoxic and
nonirritant material. However, ingestion of large quantities may be
harmful.
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg
Lager
Triethyl citrate should be stored in a closed container in a cool, dry
location. When stored in accordance with these conditions, triethyl
citrate is a stable product.
Inkompatibilit?ten
Triethyl citrate is incompatible with strong alkalis and oxidizing
materials.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal
Ingredients.
Triethylcitrat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
