1,2-Bis(maleimido)ethane
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- CAS-Nr.
- 5132-30-9
- Englisch Name:
- 1,2-Bis(maleimido)ethane
- Synonyma:
- BMOE;1,6-BISMALEIMIDOETHANE;EBM;NSC 41127;BM&œBIS-MALEIMIDOETHANE;1,2-DiMaleiMidoethane;ETHYLENE-BIS-MALEIMIDE;1,2-BISMALEIMIDOETHANE;1,2-BIS(MALEIMIDE)ETHANE
- CBNumber:
- CB5476024
- Summenformel:
- C10H8N2O4
- Molgewicht:
- 220.18
- MOL-Datei:
- 5132-30-9.mol
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1,2-Bis(maleimido)ethane Eigenschaften
- Schmelzpunkt:
- 193-194°C
- Siedepunkt:
- 428.3±28.0 °C(Predicted)
- Dichte
- 1.510±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform
- Aggregatzustand
- Solid
- pka
- -2.11±0.20(Predicted)
- Farbe
- Off White
- InChI
- InChI=1S/C10H8N2O4/c13-7-1-2-8(14)11(7)5-6-12-9(15)3-4-10(12)16/h1-4H,5-6H2
- InChIKey
- PUKLCKVOVCZYKF-UHFFFAOYSA-N
- SMILES
- C(N1C(=O)C=CC1=O)CN1C(=O)C=CC1=O
- CAS Datenbank
- 5132-30-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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1,2-Bis(maleimido)ethane Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off White Solid
Verwenden
1,2-Bis(maleimido)ethane is a protein cross-linking agent.
Allgemeine Beschreibung
BMOE, BMB and BMH are homobifunctional, maleimide crosslinkers for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. Because BMOE, BMB and BMH have the same reactivity but differ in length, the relative success of these three reagents in forming crosslinks between sites in a protein oligomer or interaction can assist in determining intra- and intermolecular distances.
Synthese
1,2-Bis(maleimido)ethane was prepared from ethylenediamine and maleic anhydride using acetic anhydride as the dehydrating agent with nickel acetate and triethylamine as catalysts. To a 1-L three-necked flask fitted with a paddle stirrer, reflux condenser, and nitrogen inlet were added 300 mL of freshly distilled N, N-dimethyl formamide, 0.5 mol (49.0 g) of maleic anhydride, and 0.25 mol (98.1 g) of ethylenediamine. The temperature of the solution rose to 115°C and its opaque color changed to yellow. Stirring was after that continued for 30 minutes at 90°C. Then 0.5 g of nickel(II) acetate, 25 mL of triethylamine, and 118 mL of acetic anhydride were added to the reaction vessel while maintaining the system at 90°C for another 30 min. The reaction mixture was cooled to 30°C, poured into 2 L of ice water, and stirred for 10 min to crystallize the BMI. The resulting brown precipitate was filtered off by suction, washed twice with 1 L of water, and filtered. For further purification, the product was dissolved in 300 mL of dry acetone, refluxed with 15 g of charcoal, and filtered. The volume of the solution was reduced to 100 mL by evaporation and then kept at 0°C overnight. The resulting precipitate was filtered off by suction and dried[1].
1,2-Bis(maleimido)ethane Upstream-Materialien And Downstream Produkte
Upstream-Materialien
4,7-Epoxy-1H-isoindole-1,3(2H)-dione, 2-[2-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-epoxy-2H-isoindol-2-yl)ethyl]-3a,4,7,7a-tetrahydro-
Downstream Produkte
1,2-Bis(maleimido)ethane Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 115)Lieferanten
5132-30-9()Verwandte Suche:
- 1,1'-Ethylenebis(3-pyrroline-2,5-dione)
- 1,1'-Ethylenebis[1H-pyrrole-2,5-dione]
- N,N'-Ethylenebis(maleinimide)
- 1-(2-maleimidoethyl)-3-pyrroline-2,5-quinone
- 1-[2-(2,5-dioxopyrrol-1-yl)ethyl]pyrrole-2,5-dione
- 1,2-DiMaleiMidoethane
- 1,1'-(1,2-Ethanediyl)bis-1H-pyrrole-2,5-dione
- NSC 41127
- N,N'-Ethylenebismaleimide
N,N'-Ethylenedimaleimide
1,2-Di(maleimido)ethane
- 1H-Pyrrole-2,5-dione,1,1'-(1,2-ethanediyl)bis-
- BIS-MALEIMIDOETHANE
- ETHYLENE-BIS-MALEIMIDE
- EBM
- 1,2-BIS(MALEIMIDE)ETHANE
- 1,2-BISMALEIMIDOETHANE
- N,N'-ETHYLENEDIMALEIMIDE
- N,N'-ETHYLENEBISMALEIMIDE
- 1,2-BISMALEIMIDOETHANE 98+%
- 3,3-(Ethane-1,2-diyl)bis(1H-pyrrole-2,5-dione)
- 1,2-Bis(maleimido)ethane>
- 1,1'-(ethane-1,2-diyl)bis(1H-pyrrole-2,5-dione)
- BMOE
- 1,6-BISMALEIMIDOETHANE
- BM&&oelig
- 1,1'-(Ethane-1,2-diyl)bis(1H-pyrrole-2,5-dione)
- N,N'-Ethylenebis(maleinimide)
- 5132-30-9
- N-Substituted Maleimides, Succinimides & Phthalimides
- N-Substituted Maleimides
- pharmacetical
- Maleimide Derivatives
- N-Substituted Maleimides
- N-Substituted Maleimides, Succinimides & Phthalimides
- Cross Linking Reagents
- MTS & Sulfhydryl Active Reagents
