3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
|
|
|
- CAS-Nr.
- 420831-40-9
- Englisch Name:
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- Synonyma:
- AK-7;CS-922;AK 7, >=98%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
- CBNumber:
- CB52639218
- Summenformel:
- C19H21BrN2O3S
- Molgewicht:
- 437.35
- MOL-Datei:
- 420831-40-9.mol
|
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Eigenschaften
- Dichte
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: ≥15mg/mL
- Aggregatzustand
- powder
- pka
- 12.28±0.70(Predicted)
- Farbe
- white to tan
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
|
|
| R-S?tze: |
36 |
|
|
| S-S?tze: |
26 |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The sirtuin SIRT2 is a deacetylase which targets α-
tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-
related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-
7 is a cell-
and brain-
permeable inhibitor of SIRT2 (IC
50 = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-
7 down-
regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons
in vivo.
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 106)Lieferanten
420831-40-9()Verwandte Suche:
- N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
- SIRT2 Inhibitor,AK-7
- N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7
- AK 7, >=98%
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- AK-7
- Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
- AK-7;AK7;AK 7
- SIRT2 Inhibitor II, AK-7
- CS-922
- SIRT2 INHIBITOR II;AK7;AK 7
- SIRT2 Inhibitor II
- 420831-40-9
