5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
|
|
|
- CAS-Nr.
- 1020719-62-3
- Englisch Name:
- 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
- Synonyma:
- AMR69 D5;[2H5]-Pirfenidone;2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-;2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-;Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?;5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 );5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one;5-methyl-1-[(2,3,4,5,6-2H?)phenyl]-1,2-dihydropyridin-2-one;5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone;Pirfenidone-d5Q: What is
Pirfenidone-d5 Q: What is the CAS Number of
Pirfenidone-d5 Q: What is the storage condition of
Pirfenidone-d5 Q: What are the applications of
Pirfenidone-d5
- CBNumber:
- CB52511343
- Summenformel:
- C12H11NO
- Molgewicht:
- 185.23
- MOL-Datei:
- 1020719-62-3.mol
|
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Eigenschaften
- Schmelzpunkt:
- 104-106°C
- storage temp.
- -20°C Freezer
- L?slichkeit
- Chloroform (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Light Beige
- InChI
- InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
- InChIKey
- ISWRGOKTTBVCFA-UHFFFAOYSA-N
- SMILES
- O=C1C=CC(C)=CN1C1C([H])=C([H])C([H])=C([H])C=1[H]
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Pirfenidone-d
5 is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities. It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin . In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes
Col1a1,
Timp1,
Tgfb1,
Pdgfb, and
Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC
50s = ~6 and ~2.5 mM, respectively). Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Chemische Eigenschaften
Off-White Solid
Verwenden
A deuterated metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 41)Lieferanten
1020719-62-3()Verwandte Suche:
- 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
- 2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-
- 5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone
- Pirfenidone-d5Q: What is
Pirfenidone-d5 Q: What is the CAS Number of
Pirfenidone-d5 Q: What is the storage condition of
Pirfenidone-d5 Q: What are the applications of
Pirfenidone-d5
- Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?
- 2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-
- [2H5]-Pirfenidone
- AMR69 D5
- 5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one
- 5-methyl-1-[(2,3,4,5,6-2H?)phenyl]-1,2-dihydropyridin-2-one
- 1020719-62-3
- Aromatics
- Isotope Labelled Compounds
- Metabolites
