methyl 3-bromo-4-methyl-5-nitropicolinate
|
|
|
- CAS-Nr.
- 1150618-07-7
- Englisch Name:
- methyl 3-bromo-4-methyl-5-nitropicolinate
- Synonyma:
- methyl 3-bromo-4-methyl-5-nitropicolinate;methyl3-bromo-4-methyl-5-nitropyridine-2-carboxylate;methyl 3-bromo-4-methyl-5-nitropicolinate ISO 9001：2015 REACH;3-Bromo-4-methyl-5-nitro-2-pyridinecarboxylic acid methyl ester;2-Pyridinecarboxylic acid, 3-bromo-4-methyl-5-nitro-, methyl ester
- CBNumber:
- CB52474727
- Summenformel:
- C8H7BrN2O4
- Molgewicht:
- 275.06
- MOL-Datei:
- 1150618-07-7.mol
|
methyl 3-bromo-4-methyl-5-nitropicolinate Eigenschaften
- Siedepunkt:
- 377.2±42.0 °C(Predicted)
- Dichte
- 1.668
- storage temp.
- 2-8°C
- pka
- -4.11±0.10(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
methyl 3-bromo-4-methyl-5-nitropicolinate Chemische Eigenschaften,Einsatz,Produktion Methoden
synthetische
Methyl-3-bromo-4-methyl-5-nitropicolinate synthesis: 3-bromo-2-iodo-4-methyl-5-nitropyridine (129.0 g, 0.38 mol) and (Ph3P)2PdCl2 (7.92 g, 3 mol%) were suspended in CH3CN (1300 mL) and MeOH (430 mL) and Et3N (79.3 mL, 1.5 eq) was added. The mixture was transferred to a steel 5000 mL pressure vessel, 4 bar of CO pressure was applied and the reaction mixture was slowly heated to 80 oC. Subsequently, it was stirred for 5 h at this temperature, then allowed to cool overnight. The volatiles were removed in vacuo, the residue was stirred in EtOAc (1000 mL) and filtered. The residue was extracted with EtOAc (2*250 mL) and the combined filtrates were washed with brine (1000 mL) and dried on Na2SO4. The volatiles were removed in vacuo, affording 120 g of a brown oil. This was coated on 120 g of silicagel and purified by column chromatography (3500 g of silica gel, EtOAc/heptane 1:3, KMnO4 staining). The appropriate fractions were combined and concentrated to give Methyl-3-bromo-4-methyl-5-nitropicolinate as a beige solid (63.5 g, 61%).
methyl 3-bromo-4-methyl-5-nitropicolinate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
methyl 3-bromo-4-methyl-5-nitropicolinate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 30)Lieferanten
- methyl 3-bromo-4-methyl-5-nitropicolinate
- 2-Pyridinecarboxylic acid, 3-bromo-4-methyl-5-nitro-, methyl ester
- 3-Bromo-4-methyl-5-nitro-2-pyridinecarboxylic acid methyl ester
- methyl3-bromo-4-methyl-5-nitropyridine-2-carboxylate
- methyl 3-bromo-4-methyl-5-nitropicolinate ISO 9001：2015 REACH
- 1150618-07-7
