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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Struktur
56741-95-8
CAS-Nr.
56741-95-8
Englisch Name:
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
Synonyma:
U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone
CBNumber:
CB5225165
Summenformel:
C10H8BrN3O
Molgewicht:
266.09
MOL-Datei:
56741-95-8.mol

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Eigenschaften

Schmelzpunkt:
285-287° (Stevens); mp 246-248° (Brown, Stevens)
Siedepunkt:
389.7±52.0 °C(Predicted)
Dichte
1.6292 (rough estimate)
Brechungsindex
1.6520 (estimate)
storage temp. 
room temp
L?slichkeit
DMSO: ≥5mg/mL (warm DMSO)
Aggregatzustand
powder
pka
3.18; 8.53(at 25℃)
Farbe
white to beige
Wasserl?slichkeit
7.8mg/L(37 ºC)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 63-62
WGK Germany  3
RTECS-Nr. UW7351300
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

Verwenden

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 86)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30237 58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		+8618795957998
 karmelhk@126.com CHINA 2886 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58

56741-95-8()Verwandte Suche:

  • 2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one
  • 2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE
  • 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
  • 2-Amino-5-bromo-6-phenylpyrimidin-4-ol
  • 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one
  • 5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one
  • PNU-54461
  • U-54461
  • 2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone
  • 2-AMino-5-broMo-6-phenyl-4-pyriMidinol
  • 2-AMino-5-broMo-6-phenyl-4-pyriMidinone
  • 5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone
  • 5-BroMo-6-phenylisocytosine
  • NSC 149027
  • 4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl-
  • 2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine
  • U 54461S
  • 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon
  • 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone
  • bropirimine
  • 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
  • 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
  • 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
  • carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit
  • Bromopilimine
  • 56741-95-8
  • C10H8BrN3O
  • Heterocycle-Pyrimidine series
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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