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Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl)

Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) Struktur
70142-34-6
CAS-Nr.
70142-34-6
Englisch Name:
Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl)
Synonyma:
Polyoxyl 15 hydroxystearate;Kolliphor? HS 15;SOLUTOL(R);Kolliphor(R) HS 15;PEG-15 Octadecanoic acid;Macrogol (15)-hydroxystearate;Polyoxyl 15 Hydroxystearate (500 mg);Polyoxyethylated 12-hydroxystearic acid;POLYETHYLENEGLYCOL-30DIPOLYHYDROXYSTEARATE;12-HYDROXYSTEARICACID-POLYETHYLENEGLYCOLCOPOLYMER
CBNumber:
CB51214281
Summenformel:
(C18H36O3.(C2H4O)nH2O)x
Molgewicht:
0
MOL-Datei:
Mol file

Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) Eigenschaften

Flammpunkt:
272℃
storage temp. 
Refrigerator
L?slichkeit
Very soluble in water, soluble in ethanol (96 per cent), insoluble in liquid paraffin. It solidifies at about 25 °C.
Aggregatzustand
Solid
Farbe
Clear Colourless Oil to Off-White
Geruch (Odor)
magnolia white flower fresh citrus natural
PH
5.0-7.0 (1g/10 mL in H2O)
EPA chemische Informationen
Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) (70142-34-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 43
S-S?tze: 24-37
WGK Germany  3
HS Code  3907990100
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Yellowish, waxy mass.

Verwenden

Non-ionic surfactant.

Vorbereitung Methode

Macrogol 15 hydroxystearate is produced by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxystearic acid.

Pharmazeutische Anwendungen

Macrogol 15 hydroxystearate is frequently used in preclinical testing of drugs, mainly for IV and other parenteral applications. The solubilizing capacity for some tested drugs (clotrimazole, carbamazepine, 17 β-estradiol, sulfathiazole, and piroxicam) increases almost linearly with increasing concentration of solubilizing agent. This is due to the formation of spherical micelles even at high concentrations of macrogol 15 hydroxystearate. Similarly, tests have revealed that viscosity increases with increasing amount of solubilizer, but the amount of solubilized drugs does not have any additional influence on the kinematic viscosity. Lipid nanocapsules comprising macrogol 15 hydroxystearate and soybean phosphatidylcholine containing 3% docetaxel have been successfully prepared by a solvent-free inversion process.
Macrogol 15 hydroxystearate has been used in the manufacture of aqueous parenteral preparations with vitamin A, D, E and K, and a number of other lipophilic pharmaceutical active agents, such as propanidid, miconazole, alfadolone, and alfaxalone. It is very efficient at solubilizing substances like fat-soluble vitamins and active ingredients of hydrophobic nature. It is also an excellent solubilizer for parenteral use, at a concentration of 20%, and the water solubility of different drugs may be enhanced by a factor of 10–100, depending on the structure of the drug molecule.

Sicherheit(Safety)

Macrogol 15 hydroxystearate is used in parenteral pharmaceutical preparations in concentrations up to 50% to solubilize diclofenac, propanidid, and vitamin K1. It has also been used in preclinical formulations in preparing supersaturated injectable formulations of water-insoluble molecules. It is generally regarded as a relatively nontoxic and nonirritant excipient.
Macrogol 15 hydroxystearate is reported not to be mutagenic in bacteria, mammalian cell cultures and mammals.
LD50 (dog, IV): >3.10 g/kg
LD50 (mouse, IP): >0.0085 g/kg
LD50 (mouse, IV): >3.16 g/kg
LD50 (rabbit, IV): 1.0–1.4 g/kg
LD50 (rat, oral): >20 g/kg
LD50 (rat, IV): 1.0–1.47 g/kg

Lager

Macrogol 15 hydroxystearate has a high chemical stability. The prolonged action of heat may induce physical separation into a liquid and a solid phase after cooling, which can be reversed by subsequent homogenization. Macrogol 15 hydroxystearate is stable for at least 24 months if stored in unopened airtight containers at room temperature (maximum 25 °C). Aqueous solutions of macrogol 15 hydroxystearate can be heat-sterilized (121°C, 0.21 MPa). The pH may drop slightly during heating, which should be taken into account. Separation into phases may also occur, but agitating the hot solution can reverse this. Aqueous solutions can be stabilized with the standard preservatives used in pharmaceuticals.
Macrogol 15 hydroxystearate should be stored in tightly sealed containers in a dry place.

Regulatory Status

Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 11817 58
Alfa Chemistry

Info@alfa-chemistry.com United States 24072 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Hebei Weibang Biotechnology Co., Ltd
+8615350571055
Sibel@weibangbio.com China 6086 58

  • Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl)
  • POLYETHYLENEGLYCOL-30DIPOLYHYDROXYSTEARATE
  • 12-HYDROXYSTEARICACID-POLYETHYLENEGLYCOLCOPOLYMER
  • SOLUTOL(R)
  • 12-Hydroxystearinsure, ethoxyliert 16,6 EO (mittleres Molekulargewicht ca. 1070)
  • Polyoxyl 15 Hydroxystearate (500 mg)
  • Polyoxyethylated 12-hydroxystearic acid
  • Macrogol (15)-hydroxystearate
  • Polyethylene Glycol 15-Hydroxystearate (Technical Grade, contains up to 35% polyethylene glycol)
  • Kolliphor(R) HS 15
  • 11-hydroxy-17-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]heptadecanoicaci
  • Polyoxyl 15 hydroxystearate
  • Kolliphor? HS 15
  • Octadecanoic acid, 12-hydroxy-, polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)
  • PEG-15 Octadecanoic acid
  • 70142-34-6
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