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ANTI-CASPASE-12

ANTI-CASPASE-12 Struktur
CAS-Nr.
Englisch Name:
ANTI-CASPASE-12
Synonyma:
ANTI-CASPASE-12;MONOCLONAL ANTI-CASPASE 12;ANTISERUM TO CASPASE-12 (NT);POLYCLONAL ANTIBODY TO CASPASE-12 (NT);Anti-Caspase-12 (small) antibody produced in rabbit;Anti-Caspase-12 (large) antibody produced in rabbit;Monoclonal Anti-Caspase 12 antibody produced in rat
CBNumber:
CB4677350
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-CASPASE-12 Eigenschaften

storage temp. 
−20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

ANTI-CASPASE-12 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-Caspase 12 has been used in immunoblotting and immunocytochemistry (4% paraformaldehyde-fixed, paraffin-embedded).

Allgemeine Beschreibung

Caspase 12 is a protein that belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The human caspase 12 gene is localized at a single locus within the caspase 1/ICE gene cluster on chromosome 11q22. The functionality is lost in humans and they cannot play a role in Alzheimer′s disease. Caspase-12 is detected in endoplasmic reticulum (ER), plays a role in ER-mediated apoptosis and inflammatory caspase activation pathway.

Biochem/physiol Actions

Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion. Casp12 might stimulate nuclear factor-κB (NF-κB) by directing the post-translational degradation of inhibitor of kappa B (IκBα). Overexpression of caspase 12 induces apoptosis, which is inhibited by the pan caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethyl ketone (z-VAD-FMK).

ANTI-CASPASE-12 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-CASPASE-12 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 6)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Riedel-de Haen AG --
United States 6773 87
SIGMA-RBI --
Switzerland 6896 91
Kamiya Biomedical Company --
ordering@kamiyabiomedical.com United States 736 72
Fluorochem Ltd. --
enquiries@fluorochem.co.uk United Kingdom 6401 74
BD Biosciences --
United States 5013 82
MP Biomedicals, Inc. --
United States 6561 81

  • Anti-Caspase-12 (large) antibody produced in rabbit
  • Anti-Caspase-12 (small) antibody produced in rabbit
  • ANTI-CASPASE-12
  • ANTISERUM TO CASPASE-12 (NT)
  • POLYCLONAL ANTIBODY TO CASPASE-12 (NT)
  • MONOCLONAL ANTI-CASPASE 12
  • Monoclonal Anti-Caspase 12 antibody produced in rat
  • 1
  • Alphabetical Index
  • Antibodies
  • Antibodies to Caspases
  • Apoptosis Enzymes
  • Clone Index
  • C1 to CACell Signaling Enzymes
  • Caspase 11, 12, and 13Antibodies for Apoptosis
  • Caspase 12Antibodies
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