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ANTI-NICASTRIN

ANTI-NICASTRIN Struktur
CAS-Nr.
Englisch Name:
ANTI-NICASTRIN
Synonyma:
Anti-APH-2;Anti-MGC2993;ANTI-NICASTRIN;Anti-Anterior pharynx defective 2;Anti-ZDHHC16 antibody produced in rabbit;Anti-Zinc finger, DHHC-type containing 16;Anti-Nicastrin antibody produced in rabbit;Anti-Nicastrin (ab2) antibody produced in rabbit;Anti-Nicastrin (ab1) antibody produced in rabbit
CBNumber:
CB4487092
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-NICASTRIN Eigenschaften

storage temp. 
−20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

Kennzeichnung gef?hrlicher Xn
R-S?tze: 21/22-52/53
S-S?tze: 36/37-61
WGK Germany  -

ANTI-NICASTRIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-Nicastrin antibody produced in rabbit has been used in:
  • western blotting
  • immunoprecipitation
  • co-immunoprecipitation

Allgemeine Beschreibung

Nicastrin (NCSTN) is a type I transmembrane glycoprotein (709 amino acids) that interacts with both presenilin-1 (PS1) and presenilin-2 (PS2). This gene is located on human chromosome 1q23.

Biochem/physiol Actions

Nicastrin has a key role in the regulation of presenilin-mediated cleavage of the b-amyloid precursor protein (b-APP) and Notch/GLP-1. Nicastrin binds to the membrane-tethered form of Notch and is essential for the intramembrane cleavage of Notch to generate Notch intracellular domain (NICD), which is involved in intracellular signaling. It has been suggested that nicastrin binds substrates of presenilin/g-secretase complexes or modulates g-secretase activity. Suppression of nicastrin expression in C. elegansembryos induces a subset of notch/glp-1 phenotypes similar to those induced by simultaneous null mutations in both presenilin homologues of C. elegans (sel-12 and hop-1). Thus, increasing evidence indicates that both nicastrin and presenilins are necessary components for the intramembrane proteolysis of proteins such as b-APP and Notch, and implicates a direct role for nicastrin in the pathogenesis of Alzheimer′s disease and in the regulation of Notch signaling in vivo.

ANTI-NICASTRIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-NICASTRIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 5)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
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  • ANTI-NICASTRIN
  • Anti-Nicastrin antibody produced in rabbit
  • Anti-Nicastrin (ab1) antibody produced in rabbit
  • Anti-MGC2993
  • Anti-ZDHHC16 antibody produced in rabbit
  • Anti-Zinc finger, DHHC-type containing 16
  • Anti-Anterior pharynx defective 2
  • Anti-APH-2
  • Anti-Nicastrin (ab2) antibody produced in rabbit
  • Alphabetical Index
  • Antibodies for Alzheimer and Neurodegenerative Disease ResearchAntibodies
  • Antibodies for Neurobiology
  • Antibodies for Neurodegenerative Diseases Research
  • N
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