6-HYDROXYMELATONIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

6-hydroxy Melatonin is an active metabolite of melatonin . It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT_1A), MT_1B, and MT₂ receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC₅₀ = 0.0016 μM). 6-hydroxy Melatonin (10 and 100 μM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis. It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.

Chemische Eigenschaften

Off-White to Pale Beige Solid

Verwenden

6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.

Definition

ChEBI: A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6.

Allgemeine Beschreibung

6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.

6-HYDROXYMELATONIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-HYDROXYMELATONIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18150	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69

2208-41-5()Verwandte Suche:

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• N-Acetyl-5-methoxy-6-hydroxy-1H-indole-3-ethanamine
• N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]ethanamide
• Sutan (Butylate)
• MELATONIN, 6-HYDROXY
• 3-[N-ACETYLAMINOETHYL]-6-HYDROXY-5-METHOXYINDOLE
• 6-HYDROXYMELATONIN
• 6-HYDROXY-N-ACETYL-5-METHOXYTRYPTAMINE
• N-ACETYL-6-HYDROXY-5-METHOXYTRYPTAMINE
• n-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-acetamid
• N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
• 3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol
• N-[2-(5-Methoxy-6-hydroxy-1H-indole-3-yl)ethyl]acetamide
• Acetamide, N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-
• Melatonin 6-Hydroxy Impurity
• Melatonin Impurity 3 (6-Hydroxy Melatonin)
• 6-Hydroxymelatonine
• 6Hydroxymelatonin,6 Hydroxymelatonin
• 2208-41-5
• Aromatics
• Heterocycles
• Intermediates & Fine Chemicals
• Metabolites & Impurities
• Pharmaceuticals
• Sulfur & Selenium Compounds
• Various Metabolites and Impurities
• Metabolites