Bakuchiol
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- CAS-Nr.
- 10309-37-2
- Englisch Name:
- Bakuchiol
- Synonyma:
- BAKUCHIOL;Backuchiol;Drupanol;(S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol;UP 256;BAKUCHIOL;Aids046581;Aids-046581;98%Bakuchiol;BAKUCHIOL(SH)
- CBNumber:
- CB4365255
- Summenformel:
- C18H24O
- Molgewicht:
- 256.38
- MOL-Datei:
- 10309-37-2.mol
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Bakuchiol Eigenschaften
- Siedepunkt:
- 391℃
- Dichte
- 0.963
- Dampfdruck
- 0Pa at 25℃
- Brechungsindex
- 1.4500 (estimate)
- Flammpunkt:
- 177℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
- Aggregatzustand
- Liquid
- pka
- 10.10±0.26(Predicted)
- Farbe
- Oil
- Optische Aktivit?t
- [α]/D +24.0 to +30.0°, c = 0.1 in chloroform
- BRN
- 3611720
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChIKey
- LFYJSSARVMHQJB-WYMLVPIESA-N
- LogP
- 5.09 at 20℃ and pH6.31
- Oberfl?chenspannung
- 43.92mN/m at 1g/L and 20℃
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
SL3785000 |
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| Toxizit?t |
LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Bakuchiol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects.
Verwenden
(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol
is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.
Biologische Aktivit?t
Bakuchiol (BAK) has various pharmacological effects such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, antidiabetic, cardioprotective, and estrogen-like effects. BAK exhibits antimicrobial activity against oral microorganisms such as Streptococcus mutans. It is also a DNA polymerase inhibitor and showed anti-tumour activity in human lung adenocarcinoma A549 cells. BAK showed hepatoprotective activity in vitro and in vivo against liver injury in rats.
Sicherheitsprofil
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes.
Mode of action
The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6].
Bakuchiol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Bakuchiol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 338)Lieferanten
10309-37-2()Verwandte Suche:
- P-(3,7-DIMETHYL-3-VINYLOCTA-TRANS-1,6-DIMETHYL) PHENOL
- 7-dimethyl-1,6-octadienyl)-4-(3-ethenyl-(s-(e))-pheno
- BACTRIS GASIPAES FRUIT JUICE
- (S)-Bakuchiol
- 4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadienyl]phenol
- 4-[(1E,3S)-3-Vinyl-3,7-dimethyl-1,6-octadienyl]phenol
- 4-[(S,E)-3-Ethenyl-3,7-dimethyl-1,6-octadienyl]phenol
- Aids046581
- Aids-046581
- Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]-
- BAKUCHIOL(SH)
- (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dienyl)phenol
- 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol
- UP 256
- 4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL
- BAKUCHIOL(RG)
- 4-[(1E,3S)-3-ethenyl-3,7-diMethyl-1,6-octadienyl]-Phenol
- 4-(3,7-Dimethyl-3-vinylocta-1,6-dien-1-yl)phenol
- 4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadien-1-yl]phenol
- 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol
- Nano Liposomal (S)-(+)-Bakuchiol
- Bakuchiol 98%
- Bakuchiol, 98%, from Psoralea corylifolia L.
- Bakuchiol powder
- Bakuchiol ((S)-(+)-Bakuchiol)
- Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-
- 98% pure Bakuchiol
- 98%Bakuchiol
- (+)-Bakuchiol
- (1e 3s)-3-enthenyl-3 7-dimethyl octa-1 6-dienyl]phenol
- TIANFU CHEM 4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL
- BAKUCHIOL
- Drupanol
- Backuchiol
- (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol
- Nano-Liposomal BAKUCHIOL, Water-Soluble BAKUCHIOL
- BAKUCHIOL
- Cullen corylifolium
- Psoralen phenol
- 10309-37-2
- 10309-27-2
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
