6-Gingerol
|
|
|
- CAS-Nr.
- 23513-14-6
- Englisch Name:
- 6-Gingerol
- Synonyma:
- GINGEROL;Gingerols;rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one;6-GINGEROL;GINGEROL [6];(s)-3-decanon;6-Gingerol-RM;6-Gingerol ,98%;6-Gingerol std.;[6]-Gingerol>
- CBNumber:
- CB4328683
- Summenformel:
- C17H26O4
- Molgewicht:
- 294.39
- MOL-Datei:
- 23513-14-6.mol
|
6-Gingerol Eigenschaften
- Schmelzpunkt:
- 31℃
- Siedepunkt:
- 453.0±35.0 °C(Predicted)
- Dichte
- 1.083±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- methanol: soluble1mg/mL, clear, colorless
- Aggregatzustand
- Pale yellow oil
- pka
- 10.02±0.20(Predicted)
- Farbe
- White to Light yellow
- InChI
- InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
- InChIKey
- NLDDIKRKFXEWBK-AWEZNQCLSA-N
- SMILES
- C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCC
- LogP
- 2.485 (est)
- CAS Datenbank
- 23513-14-6(CAS DataBase Reference)
- NIST chemische Informationen
- Gingerol(23513-14-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22-36/37/38 |
|
|
| S-S?tze: |
26-36/37 |
|
|
| RIDADR |
UN 2811 6.1 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
HE0757000 |
|
|
| HS Code |
29145090 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
6-Gingerol Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light yellow ceraceous solid
Verwenden
[6]-Gingerol has been used:
- to study its effects on transient receptor potential (TRP) channels
- to study its effects on experimental models of non-alcoholic steatohepatitis
- to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line
- to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice
Definition
ChEBI:Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.
Allgemeine Beschreibung
6-Gingerol is a naturally occurring plant phenoland an active pungent constituent found in the rhizome of ginger, which is known to possess anti-inflammatory, anti-tumor and antioxidant properties and can hence, serve as a potential candidate in the treatment of cancer.
Anticancer Research
6-Gingerol is a plant polyphenol and an active constituent of Zingiber officinale, which shows antioxidant, anti-inflammation, and antitumor properties. It has been reported to possess anti-cancer and chemopreventive potentials against several cancers, including skin, colorectal, gastrointestinal and pancreatic. It can inhibit NOS, TNF-α, and COX-2 enzymes, which are regulated by NF-κB. It hinders the cell growth of prostate, gastric, and breast cancer cells and suppresses the lung metastasis of B16F10 melanoma. It exhibits an antitumorigenic effect in human colorectal cancer cells via upregulating NSAID-activated gene-1 (NAG-1). Italters ERK1/2/JNK/AP1 pathway and induces apoptosis in colon cancer cells in acaspase-dependent manner. ROS levels were significantly increased in K562 and MOLT4 cells treated with gingerol, and apoptosis was induced in leukaemia cells by the mitochondrial pathway.
6-Gingerol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-Gingerol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 412)Lieferanten
23513-14-6()Verwandte Suche:
- (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
- (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
- (S)-8-Oxo-10-(3-methoxy-4-hydroxyphenyl)decane-6-ol
- 6-Gingerol ,98%
- 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-,
(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
- (5S)-[6]-Gingerol
- 1-(4'-HYDROXY-3'-METHOXYPHENYL)-5-HYDROXY-3-DECANONE
- 6-GINGEROL
- [6]-GINGEROL, ZINGIBER OFFICINALE
- (5s)-5-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one
- GINGEROL [6]
- (S)-5-HYDROXY-1-(4-HYDROXY-3-METHOXY-PHENYL-3-DECANONE
- 5-HYDROXY-1-(4'-HYDROXY-3'-METHOXYPHENYL)-3-DECANONE
- (s)-(+)-(6)gingerol
- (s)-(+)-3-decanon
- 6-Gingerol, froM Zingiber officinale
- (s)-(6)-gingerol
- (s)-3-decanon
- 6-Gingerol std.
- 6-GINGEROL, 98% HPLC
- 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)
- [6]-Gingerol>
- [6]-Gingerol Standard
- (+)-[6]-Gingerol
- 6-Gingerol USP/EP/BP
- 3-Decanone,5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-
- 6-Gingerol, 98%, from Zingiber officinale Rosc.
- [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem
- 6-Gingerol 23513-14-6
- GINGEROL
- Gingerols
- rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one
- Gingerol (6-Gingerol)
- Green Tea Extract Catechin
- Ginger Extract Gingerol
- 6-Gingerol-RM
- Pyrroloquinoline Impurity 5
- 23513-14-6
- C17H26O4
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Aromatic Phenols
- Natural Plant Extract
- The group of Ginerols
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- Elisa Kit-plant ELISA Kit
- 23513-14-6
