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7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on

N-desalkylflurazepam Struktur
2886-65-9
CAS-Nr.
2886-65-9
Bezeichnung:
7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on
Englisch Name:
N-desalkylflurazepam
Synonyma:
DESALKYLFLURAZEPAM;NORFLUDIAZEPAM;N-desallkylflurazepam;FlurazepaM Related CoMpound F;cm7116;ro5-3367;sch17514;MMK1 TFA;RO 5-3367;nor-Flurazepam
CBNumber:
CB4316060
Summenformel:
C15H10ClFN2O
Molgewicht:
288.7
MOL-Datei:
2886-65-9.mol

7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on Eigenschaften

Schmelzpunkt:
204-206°C
Siedepunkt:
454.0±45.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
Flammpunkt:
9℃
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
A neat solid
pka
11.55±0.70(Predicted)
Farbe
White to off-white
InChI
InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey
UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES
N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O
CAS Datenbank
2886-65-9(CAS DataBase Reference)
NIST chemische Informationen
Norfludiazepam(2886-65-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T
R-S?tze: 11-23/24/25-39/23/24/25
S-S?tze: 22-24/25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS-Nr. DF2370100
HS Code  2933997500
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P403+P233 An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.

Chemische Eigenschaften

Light Yellow Solid

Verwenden

The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase

Allgemeine Beschreibung

N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Mode of action

N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine 2-Brom-4'-chlor-2'-(o-fluorbenzoyl)acetanilid 2-Chlor-N-[4-chlor-2-(2-fluorbenzoyl)phenyl]acetamid N-(tert-Butoxycarbonyl)glycin

Downstream Produkte

Flualprazolam 2-Amino-5-chlor-2'-fluorbenzophenon 4-Imidazolidinone, 1,1'-methylenebis[3-[4-chloro-2-(o-fluorobenzoyl)phenyl]- (7CI,8CI) Midazolam [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE

2886-65-9(7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on)Verwandte Suche:

  • Dealkylflurazepam
  • Descarbethoxyloflazepate
  • Flurazepam M (des-alkyl)
  • Flurazepam M (N-1-des-alkyl)
  • Flurazepam, des-alkyl
  • N-1-desalkyl-flurazepam
  • N-Desalkyl-2-oxoquazepam
  • N-Desalkylflurazepam
  • N-Desalkylflutoprazepam
  • norflutoprazepam
  • RO 5-3367
  • 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-2h-4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-
  • 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one
  • ro5-3367
  • sch17514
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-1,4-BENZODIAZEPIN-2-ONE
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
  • 5-(2-FLUOROPHENYL)-7-CHLORO-1,4-BENZODIAZEPIN-2-ONE
  • cm7116
  • DESALKYLFLURAZEPAM,100/MLINMETHANOL
  • nor-Flurazepam
  • Flurazepam Related Compound F (50 mg) (7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
  • 7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
  • 7-chloro-5-(2-fluorophenyl)- 1,4-Benzodiazepin-2-one
  • desalkylflurazepam Solution, 100ppm
  • Desalkylflurazepam solution
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDROXY-4-BENZODIAZEPIN-2-ONE
  • 5-(2-Fluorophenyl)-1,3-dihydro-7-chloro-2H-1,4-benzodiazepin-2-one
  • DESALKYLFLURAZEPAM,1.0MG/MLINMETHANOL
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3- DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 98.0% MIN
  • 2H-1,4-BENZODIAZEIN-2-ONE-7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO
  • 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
  • 5-(2-Fluorophenyl)-1,3-dihydro-7-chloro-2H-1,4-benzodiazepin-2-oneNorfludiazepam
  • 5-(2-Fluorophenyl)-7-chloro-1,3-dihydro-3H-1,4-benzodiazepin-2-one
  • Flurazepam Related Compound F Solution, 100ppm
  • Midazolam Impurity F
  • Desalkylflurazepam (CRM)
  • Midazolam Impurity 6(Midazolam EP Impurity F)
  • Midazolam ImpurityⅠ:7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam Hydrochloride ImpurityⅠ：7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • nor-Flurazepam (1.0 mg/mL in Methanol)
  • Flurazepam Related Compound F(Secondary Standards traceble to USP)
  • TIANFU CHEM 7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam Hydrochloride ImpurityⅠ：7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Midazolam ImpurityⅠ:7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam Related Compound F (7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) (1285603)
  • 7-Chloro-5-(2-fluoropheny)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • NORFLUDIAZEPAM
  • DESALKYLFLURAZEPAM
  • FlurazepaM Related CoMpound F
  • N-desallkylflurazepam
  • Flurazepam USP Related Compound F
  • N-Desalkylflurazepam, Norflurazepam
  • Flurazepam-N-desalkyl
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