Anti-Scavenger receptor class B member 2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-LIMP2 antibody produced in rabbit has been used in immunofluorescence?(1:100) and western blotting.
Allgemeine Beschreibung
Lysosomal integral membrane protein type 2 (LIMP2) is an
N-glycosylated type III transmembrane protein. It is composed of a lumenal domain, two?transmembrane domains, and a cytoplasmic domain. LIMP2 belongs to the?CD36?family of?scavenger receptor?proteins and is found abundantly in the lysosome. The LIMP2 gene is located on the human chromosome at 4q21.1.
Biochem/physiol Actions
Lysosomal integral membrane protein type 2 (LIMP2) binds to β-glucocerebrosidase. Mutations in the LIMP 2 gene are associated with action myoclonus-renal failure syndrome, a fatal autosomal recessive disorder. Higher levels of LIMP2 lead to enlargement of early or late endosomes/lysosomes. Overexpression of LIMP2 is associated with impairment of endocytotic membrane trafficking.
Anti-Scavenger receptor class B member 2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
