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PF 04995274

PF 04995274 Struktur
1331782-27-4
CAS-Nr.
1331782-27-4
Englisch Name:
PF 04995274
Synonyma:
PF 04995274;PF04995274;PF 04995274;PF-04995274 >=98% (HPLC);4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol;(R)-4-((4-(((4-((Tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol;2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-;Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
CBNumber:
CB42668576
Summenformel:
C23H32N2O6
Molgewicht:
432.51
MOL-Datei:
1331782-27-4.mol

PF 04995274 Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM)
Aggregatzustand
A crystalline solid
Farbe
White to off-white

Sicherheit

PF 04995274 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

PF 04995274 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PF 04995274 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 37)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
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ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
Taizhou Tongxin Bio-Tech Co., Ltd 0523-18601685-898 18652728585
 sales@allyrise.com China 2782 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4566 55
Taizhou Ruixin Chemical Co., Ltd. 0576-89085261 15867635987
 jasonhu09@163.com China 442 50
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
  • PF 04995274
  • PF-04995274 >=98% (HPLC)
  • 2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-
  • PF04995274;PF 04995274
  • 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
  • Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
  • (R)-4-((4-(((4-((Tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol
  • 1331782-27-4
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