RP107
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RP107 Eigenschaften
- Schmelzpunkt:
- 281-283°C
- Dichte
- 1.227
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Yellow solid
- pka
- 9.67±0.15(Predicted)
- Farbe
- Light Orangish Yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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RP107 Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Yellow solidVerwenden
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,Allgemeine Beschreibung
A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC50 = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC50 = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC50 = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC50 ≥ 100 μM). Shown to arrest cells in both G1 and G2 phases (IC50 = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC50 = 150 nM, 140 nM and 111 nM, respectively).RP107 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
RP107 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 67)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32302 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30230 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 5221 | 58 |
TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 19904 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131957 | 58 |
J & K SCIENTIFIC LTD. | 18210857532 |
jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15839 | 69 |
Shanghai Paulshine Chemical Co., Ltd. | +86-021-37788663 |
China | 186 | 64 |
496864-16-5()Verwandte Suche:
- RP107
- 4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL
- ALOISINE A
- ALOISINE A RP107
- 7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE
- 7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
- RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
- RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine
- 4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
- 7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
- Aloisine A - CAS 496864-16-5 - Calbiochem
- Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-
- 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one
- 4-(7-butyl-l,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-l-one
- Aloisine A, CDK inhibitor
- 496864-16-5
- All Inhibitors
- Inhibitors
- Protein Kinase Inhibitors and Activators
- Aromatics
- Heterocycles