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RP107

RP107 Struktur
496864-16-5
CAS-Nr.
496864-16-5
Englisch Name:
RP107
Synonyma:
RP107;ALOISINE A;ALOISINE A RP107;Aloisine A - CAS 496864-16-5 - Calbiochem;4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-;7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
CBNumber:
CB4265483
Summenformel:
C16H17N3O
Molgewicht:
267.33
MOL-Datei:
496864-16-5.mol

RP107 Eigenschaften

Schmelzpunkt:
281-283°C
Dichte
1.227
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Yellow solid
pka
9.67±0.15(Predicted)
Farbe
Light Orangish Yellow
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
R-S?tze: 36/37/38
S-S?tze: 26-36/37
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

RP107 Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Yellow solid

Verwenden

A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,

Allgemeine Beschreibung

A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC50 = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC50 = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC50 = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC50 ≥ 100 μM). Shown to arrest cells in both G1 and G2 phases (IC50 = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC50 = 150 nM, 140 nM and 111 nM, respectively).

RP107 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


RP107 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 5221 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19885 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15839 69
Shanghai Paulshine Chemical Co., Ltd. +86-021-37788663
China 186 64

496864-16-5()Verwandte Suche:


  • RP107
  • 4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL
  • ALOISINE A
  • ALOISINE A RP107
  • 7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE
  • 7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
  • RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
  • RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine
  • 4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
  • 7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
  • Aloisine A - CAS 496864-16-5 - Calbiochem
  • Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-
  • 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one
  • 4-(7-butyl-l,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-l-one
  • 496864-16-5
  • All Inhibitors
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Aromatics
  • Heterocycles
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