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CC0651

CC0651 Struktur
1319207-44-7
CAS-Nr.
1319207-44-7
Englisch Name:
CC0651
Synonyma:
CC0651;CC0651,CC-0651;(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
CBNumber:
CB42627678
Summenformel:
C20H21Cl2NO6
Molgewicht:
442.29
MOL-Datei:
1319207-44-7.mol

CC0651 Eigenschaften

Siedepunkt:
755.7±60.0 °C(Predicted)
Dichte
1.410±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO: ≥ 56 mg/mL (126.61 mM)
pka
3.37±0.34(Predicted)
Aggregatzustand
Powder
Farbe
White to off-white

Sicherheit

CC0651 Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

CC0651 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CC0651 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 38)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135
 zijue.cai@tsbiochem.com United States 19885 58
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
LETOPHARM LIMITED +86-21-5821 5861
sales@letopharm.com China 2384 58
SPIRO PHARMA
eric_feng1954@126.com China 9248 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195
505721671@qq.com China 3866 58

1319207-44-7()Verwandte Suche:

  • L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
  • CC0651
  • 4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid
  • (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
  • CC0651,CC-0651
  • 1319207-44-7
  • C20H21Cl2NO6
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