[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden

Synthese

[4-(2-Amino-ethyl)-phenyl]-carbamic acid tert-butyl ester is synthesised using 4-tert-butoxycarbonylaminophenylacetonitrile as a raw material by chemical reaction. The specific synthesis steps are as follows:
To a solution of (300 gm, 1.29 moles) N-BOC-4-aminophenylacetonitrile in 3000 ml of methanol, 25% aq. ammonia solution (480 ml) and Raney nickel (45 gm) were added at 25 -30°C. Reaction mixture was subjected to hydrogenation at 50-60 PSI for 4 hrs. After completion of reaction, as indicated from TLC, reaction mixture was filtered and washed with (2 X 25 ml) methanol. Filtrate was concentrated under vacuum and resulting residue was treated with (1500 ml) 1M aq. hydrochloric acid at 25-30°C. Reaction mixture was stirred for 15 minutes and filtered to remove insoluble impurities. Filtrate was basified to pH 10-12 with 50% aq. NaOH solution below 25°C. Precipitated 4-(2-aminoethyl)-N-(tert-butoxycarbonyl) phenylamine was filtered and washed with (2 X 100 ml) water. Solid was dried under vacuum at 55- 60°C for 8-10 hrs. Dry weight: 240 gm (79%). 1H NMR (CDC13 and 400 MHz): δ 1.11 (2H, s), 1.51 (9H, s), 2.68 (2H, t), 2.93 (2H, t), 6.72 (1H, s), 7.10 (2H, d), 7.28 (2H, d).

[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
SHANDONG OUCHEM CO.,LTD.	+86-18506360988 +86-18506360988	wtaili@ouchem.cn	China	51	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Shanghai XinKai Chemical Technology Co., Ltd.	021-58930698 15921516558	zhangyichao84@126.com	China	910	55
JW & Y Pharmlab Co., Ltd.	021-64340559 13651849907;	xinyu_shi@jwypharmlab.com.cn	China	12036	58
BePharm Ltd	400-685-9117	market@bepharm.com	China	15081	60
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	lucy@atkchemical.com	China	9952	58
Amatek Scientific Co. Ltd.	0512-56316828	info@amateksci.com	China	28806	58
Hefei Molake Biotechnology Co., Ltd.	0551-66336380 18956014586	983438788@qq.com	China	2158	58
Shanghai zhigan biotechnology co., LTD		zhiqianbio@126.com	China	19778	58
Shanghai Kaiwei Chemical Technology Co., Ltd.	021-58461859 15821823057	service@aiviche.com	China	49312	58

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• [4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER
• tert-Butyl (4-(2-aminoethyl)phenyl)carbamate
• Carbamic acid, N-[4-(2-aminoethyl)phenyl]-, 1,1-dimethylethyl ester
• 4-(2-Aminoethyl)-N-Boc-aniline
• 457631-44-6