(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE
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- CAS-Nr.
- 42542-10-9
- Englisch Name:
- (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE
- Synonyma:
- Methylenedioxymethamphetamine;XTC;3,4-MDMA;C07577;ecstacy;DL-MDMA;(+/-)-MDMA;AURORA KA-7748;(±)-MDMA solution;3,4-METHYLENDIOXYMETHAMPHETAMIN
- CBNumber:
- CB4221584
- Summenformel:
- C11H15NO2
- Molgewicht:
- 193.25
- MOL-Datei:
- 42542-10-9.mol
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(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE Eigenschaften
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
F,T |
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| R-S?tze: |
11-23/24/25-39/23/24/25 |
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| S-S?tze: |
7-16-36/37-45 |
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| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
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| WGK Germany |
1 |
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| Giftige Stoffe Daten |
42542-10-9(Hazardous Substances Data) |
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| Toxizit?t |
A
novel psychoactive drug chemically related to the hallucinogenic
agent MDA, but reported to be non-hallucinogenic.
Obtained by direct synthesis, at high doses it is reported to
show a stimulant-like effect in animals. Its LD50 is 97 mg/kg, i.
p., 49 mg/kg, i.p., 14 mg/kg, i.v., and 22 mg/kg, i.v. in mice,
rats, dogs, and monkeys, respectively. At higher doses, MDMA
has pressor effects and produces tachycardia, and causes damage
to serotonin neurons in both rats and monkeys. The (S)-
(1)-enantiomer is more active than the (R)-(?′)-enantiomer and,
like amphetamine, the pharmacological effects may be due to a
release of endogenous monoamine neurotransmitter, probably
serotonin and/or norepinephrine. MDMA is also an inhibitor of
monoamine uptake into brain synaptosomes. Symptoms
include pronounced mydriasis, with nystagmus and jaw clenching,
and nausea also is often reported. This substance produces a feeling of well-being and euphoria and is similar in some
respects to MDA, in that it seems to enhance a sense of empathy
and emotional openness in users. Toxic reactions would
appear to occur as a result of the pressor action, and sympathomimetic
effects of the drug. No appropriate therapeutic intervention
has been reported. Peripheral adrenergic blocking
agents, or chlorpromazine, have been used, however, to prevent
death in dogs following a lethal i.v. dose of the chemically
related agent MDA. |
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| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P311 |
GIFTINFORMATIONSZENTRUM/Arzt anrufen. |
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(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Definition
ChEBI: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Stoffwechselwegen
Four biotransformation pathways of 3,4-
(methylenedioxy)methamphetamine (MDMA) in rats
are identified as N-demethylation, O-dealkylation,
deamination, and conjugation (O-methylation, O-
glucuronidation, and/or sulfation). Specific MDMA
metabolites identified are 3-hydroxy-4-
methoxymethamphetamine, 4-hydroxy-3-
methoxymethamphetamine, 3,4-
dihydroxymethamphetamine, 4-hydroxy-3-
methoxyamphetamine, 3,4-
(methylenedioxy)amphetamine (MDA), (4-hydroxy-3-
methoxyphenyl)acetone, [3,4-
(methylenedioxy)phenyl]acetone, and (3,4-
dihydroxyphenyl)acetone. MDMA is metabolized by 10 000 g rat liver supernatant to 4-hydroxy-3-
methoxymethamphetamine, 3,4-
dihydroxymethamphetamine, MDA, and [3,4-
(methylenedioxy)phenyl]acetone. Also, the 10 000 g
rat brain supernatant metabolizes MDMA to 4-hydroxy-
3-methoxymethamphetamine, 3,4-
dihydroxymethamphetamine, 4-hydroxy-3-
methoxyamphetamine, and MDA.
(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
42542-10-9()Verwandte Suche:
- 3,4-METHYLENDIOXYMETHAMPHETAMIN
- N-Methyl-3,4-methylenedioxyamphetamine
- 3,4-METHYLENDIOXYMETHAMPHETAMIN, >99% (HPLC)
- N,1-Dimethyl-2-(1,3-benzodioxole-5-yl)ethanamine
- N,α-Dimethyl-1,3-benzodioxole-5-ethanamine
- N-Methyl methyldimethoxymethylamphetamine
- N-Methyl-1-(1,3-benzodioxole-5-yl)-2-propanamine
- N-Methyl-α-methyl-3,4-(methylenebisoxy)phenethylamine
- ecstacy
- C07577
- Methanol (test (±)-MDMA, 1.0 mg/Ml)
- (±)-MDMA solution
- (+/-)-MDMA
- DL-MDMA
- AURORA KA-7748
- (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE
- (±)-MDMA [(±)-3,4-Methylenedioxymethamphetamine]
- (+/-)-3,4-MethylenedioxyMethaMphetaMin
- 1-(1,3-Benzodioxol-5-yl)-N-methyl-2-propanamine
- 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-
- 3,4-Methylenedioxymethylamphetamine
- 3,4-Methylenedioxymethylamphetamine, N-methyl-
- Methamphetamine, 3,4-methylenedioxy
- Methylenedioxymethamphetamine (MDMA)
- 1-benzo[1,3]dioxol-5-yl-N-methyl-propan-2-amine hcl.
- 1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine
- 1,3-Benzodioxole-5-ethanamine, N,α-dimethyl-
- (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE
- 3,4-MDMA
- Methylenedioxymethamphetamine
- XTC
- 42542-10-9
- 54949-52-0
- 42542-10-9 MDMA
