CHAETOMIN
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- CAS-Nr.
- 1403-36-7
- Englisch Name:
- CHAETOMIN
- Synonyma:
- CTM;CS-1;HSF4;SSFA2;CHETOMIN;CHAETOMIN;NSC 289491;CHETOMIN(RG);DKFZp313O1039;Chetomin,Chaetomin
- CBNumber:
- CB4173948
- Summenformel:
- C31H30N6O6S4
- Molgewicht:
- 710.87
- MOL-Datei:
- 1403-36-7.mol
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CHAETOMIN Eigenschaften
- Schmelzpunkt:
- 218-220℃ (chloroform )
- Dichte
- 1.78±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- Off-white to fawn solid.
- pka
- 12.69±0.10(Predicted)
- Farbe
- Off-white to fawn
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Toxizit?t |
rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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CHAETOMIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Definition
ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
Biochem/physiol Actions
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
CHAETOMIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CHAETOMIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 99)Lieferanten
1403-36-7()Verwandte Suche:
- Monoclonal Anti-HSF4 antibody produced in mouse
- DKFZp313O1039
- SSFA2
- ANTI-HSF4 antibody produced in mouse
- HSF4
- CTM
- CS-1
- CHETOMIN
- CHAETOMIN
- Chetomin,Chaetomin
- Chetomin,Chaetomiumspecies
- CHETOMIN(RG)
- NSC 289491
- Stereoisomer of 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
- (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
- Chetomin
(NSC 289491)
- 3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-, (3S,5aR,10bS,11aS)-
- NSC289491， BRN0077366
- Rabbit Anti-HSF4 antibody
- Chetomin, HIF signaling inhibitor
- 1403-36-7
- C31H30N6O6S4
