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1,8-Dihydroxyanthracen-9(10H)-on

ANTHRALIN Struktur
1143-38-0
CAS-Nr.
1143-38-0
Bezeichnung:
1,8-Dihydroxyanthracen-9(10H)-on
Englisch Name:
ANTHRALIN
Synonyma:
DITHRANOL;Anthranol;1,8,9-ANTHRACENETRIOL;9-anthrol;Rydex;Psorin;Micanol;Psorider;Batridol;Psoriderm
CBNumber:
CB4170871
Summenformel:
C14H10O3
Molgewicht:
226.23
MOL-Datei:
1143-38-0.mol

1,8-Dihydroxyanthracen-9(10H)-on Eigenschaften

Schmelzpunkt:
178-181 °C (lit.)
Siedepunkt:
464.1±45.0 °C(Predicted)
Dichte
1.419±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
Aggregatzustand
Solid
pka
7.16±0.20(Predicted)
Farbe
Yellow to Orange to Dark Yellow
Wasserl?slichkeit
Insoluble in water. Soluble in acetic acid, chloroform (20 mg/mL), acetone, benzene, solutions of alkali hydroxides, fixed oil. Slightly soluble in 95% ethanol, alcohol, ether, and glacial acetic acid.
Merck 
14,684
BRN 
2054360
Stabilit?t:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
NUZWLKWWNNJHPT-UHFFFAOYSA-N
CAS Datenbank
1143-38-0(CAS DataBase Reference)
IARC
3 (Vol. 13; Sup 7) 1987
EPA chemische Informationen
Dithranol (1143-38-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,T
R-S?tze: 36/37/38-45
S-S?tze: 26-53-45
WGK Germany  3
RTECS-Nr. CB8927000
HS Code  29144000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

1,8-Dihydroxyanthracen-9(10H)-on Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R45:Kann Krebs erzeugen.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation. It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM. Anthralin (0.25 μM) decreases the expression of β-defensin-2 and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs. It also inhibits leukotriene B4 (LTB4; ) production, stimulated by the calcium ionophore A23187 , from human neutrophils (IC50 = 7 μM). Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.

Chemische Eigenschaften

Yellow Crystalline Solid

Verwenden

Antipsoriatic

Indications

Anthralin (Anthra-Derm) is a potent reducing agent whose mechanism of action is unknown. It is approved for the treatment of psoriasis and also may be helpful in alopecia areata. The major toxicities are discoloration of skin, hair, and nails and irritant dermatitis.

Definition

ChEBI: An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.

Allgemeine Beschreibung

Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.

Air & Water Reaktionen

Unstable in air when in alkaline solution. Insoluble in water.

Reaktivit?t anzeigen

ANTHRALIN reacts as a weak acid. Soluble in aqueous bases. May react with strong oxidizing agents. May be sensitive to light and moisture .

Hazard

Very irritating. Do not use on scalp or near eyes.

Brandgefahr

Flash point data are not available for ANTHRALIN; however, ANTHRALIN is probably combustible.

Nebenwirkungen

Anthralin's side effects include pruritus, erythema, scaling, folliculitis, and lymphadenopathy. Staining of skin and clothes can also be an issue.

1,8-Dihydroxyanthracen-9(10H)-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1,8-Dihydroxyanthracen-9(10H)-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 318)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Richest Group Ltd
18017061086
oled@richest-group.com CHINA 5600 58

1143-38-0(1,8-Dihydroxyanthracen-9(10H)-on)Verwandte Suche:


  • DITHRANOL, 97+%
  • 1,8,9-ANTHRACENETRIOL, PGE. WITH 10 X 10 MG
  • 1,8,9-Trihydroxyanthracene, 97+%
  • Anthraforte
  • Micanol
  • Psorider
  • DITHRANOL,BP
  • DITHRANOL (1,8,9-TRIHYDROXYANTHRACENE)
  • Psoriderm
  • 1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin
  • 1,8-Dihydroxy-9,10-dihydroanthracene-9-one
  • Anthralin (Dithranol)
  • Dithranol,1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin
  • Anthralin (200 mg)
  • 1,8-dihydroxy-9,10-dihydroanthracen-9-one
  • 1,8-Dihydoxy-9(10H)-anthracenone
  • 1,8,9-ANTHRACENETRIOL, MATRIX SUBSTANCE FOR MALDI-MS
  • DITHRANOL, ANTHRALIN
  • ANTHRALIN
  • 1,8-DIHYDROXY-10H-ANTHRACEN-9-ONE
  • 1,8-DIHYDROXY-9(10H)-ANTHRACENONE
  • 1,8-DIHYDROXYANTHRONE
  • batridrol
  • DithraSal
  • Psorin
  • 1,8-dihydroxy-9(10h)-anthracenon
  • 1,8-dihydroxy-anthron
  • Anthrone, 1,8-dihydroxy-
  • Batridol
  • DrithoCreme
  • Drithoscalp
  • Psodadrate
  • 1,8-dihydroxyanthracen-9(10H)-one
  • Dithranol CRS
  • cignoline
  • ANTHRALIN USP/EP/BP
  • DithranolQ: What is Dithranol Q: What is the CAS Number of Dithranol Q: What is the storage condition of Dithranol
  • TIANFU CHEM---ANTHRALIN
  • ANTHRALIN Extra Pure
  • Anthralin (1039006)
  • Rydex
  • DITHRANOL
  • 9-anthrol
  • 1,8,9-ANTHRACENETRIOL
  • Anthranol
  • 1,8,9-trihydroxyanthracene|||cignoline|||Anthralin
  • 1143-38-0
  • 003-11-6
  • KETONE
  • Analytical Chromatography Product Catalog
  • BioChemical
  • Biochemicals and Reagents
  • Analytical Reagents
  • Carbohydrates
  • Polysaccharide
  • Skin drugs, treatment of psoriasis
  • API
  • ANTRADERM
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